Relationship Between Serum Levels of High

Abstract

Current study investigated the serum levels of HDL cholesterol and High Sensitivity C-Reactive Protein (HS-CRP) in 172 laborers of private firms to verify whether decrease in HDL cholesterol follows rise in HS-CRP. After a 10-14-hour fast, samples of venous blood were collected and processed for serum to be used in HS-CRP and HDL cholesterol dosage respectively by the immunoturbidimeter and enzyme-colorimeter methodology. Laborers filled a questionnaire with social, demographic, therapeutic, pathological and life style data. Data were analyzed by One-Way ANOVA test (non-parametric), followed by Bonferroni’s and Fisher’s exact tests or by the chi-square test (p<0.05). Analysis of laborers’ distribution frequency at different HDL-cholesterol bands showed a distribution frequency significantly higher for those more than 51 years old (p=0.0372*) and Body Mass Index (BMI) between 30 and 34.9 (p=0.0498*) within a low HDL-cholesterol band. A significantly high prevalence of obese subjects (p=0.0002*) and medicine consumers (p=0.0416*) was found with high HS-CRP levels. Results showed that HS-CRP levels were proportionately higher to low rates of HDL cholesterol. This fact not only reinforces the relevance of HDL cholesterol as anti-atherogenic lipid protein but also the possibility of employing the HS-CRP test in low HDL patients regardless of other changes in lipid profiles.