Evaluation of C-Reactive Protein and Fibrinogen in Advanced Stages of Chronic Obstructive Lung Disease

Abstract

Chronic Obstructive Lung Disease (COLD) comprises a chronic systemic pluricellular inflammatory syndrome characterized by a permanent inflammatory process which is not restricted to the respiratory system but predisposes to limitations of the aerial flow and other co-diseases. The analysis of proteins in the acute phase is relevant since their high concentrations are closely related to the worst forecast. Current analysis evaluated the levels of C-Reactive Protein (CRP) and Fibrinogen among patients with COLD, at stages 3 and 4. The transversal study investigated data retrieved from clinical charts of 105 COLD bearers at 3 and 4 levels complying with criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2015, attended at a reference clinic. At stage 3, the study showed a median CRP and Fibrinogen of 2.91 mg/L and 331.5 mg/dL respectively, whereas at stage 4, rates were 5.4 mg/L and 345.5mg/dL. Although COLD is 5% more severe at stage 4 when compared to that at stage 3, one cannot exclude the hypothesis of equality with regard to CRP and Fibrinogen levels between the stages. Although the levels of inflammatory markers studied differ with COLD ́s severity stage, CRP levels confirmed a higher predisposition of patients when they developed Arterial Coronary Disease.