Mechanisms Involved in the Regeneration of Peripheral Nerve Injuries

Authors

  • Carolina Kruleske da Silva Universidade Estadual de Londrina
  • Edson Amaral Camargo Universidade Estadual de Londrina

Keywords:

Peripheral Nerves, Injuries, Nerve Regeneration, Nervous System Physiological Phenomena.

Abstract

Peripheral nerve injuries are common and result in motor sensory and autonomic disability. Even in the best circumstances regeneration is rarely completely effective. The peripheral nerve regeneration involves the integration of various cellular and molecular processes followed by a series of changes observed in structures related to the injury site. In recent years the knowledge on mechanisms involved in this process has been deeply studied through clinical and experimental research. The expectation of inclusion of new treatment strategies, including neuro-engineering, molecular therapy, neuroprotective pharmacotherapy, modulation of neurotrophic factors, transplanting of embryonic cells and recent knowledge on brain plasticity secondary to these injuries may be added to current concepts of surgical and conservatory treatment for better functional results. Current study presents the main mechanisms involved in injury and regeneration of peripheral nerves and the perspectives of new treatment strategies.

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Author Biographies

Carolina Kruleske da Silva, Universidade Estadual de Londrina

Fisioterapeuta, Especialista em Ciências Fisiológicas pela Universidade Estadual de Londrina – UEL. E-mail: carolk_fisio@yahoo.com.br

Edson Amaral Camargo, Universidade Estadual de Londrina

Biomédico, Mestre em Farmacologia pela Universidade de São Paulo – USP; Doutor em Medicina e Ciências da Saúde pela Universidade Estadual de Londrina – UEL; Docente Adjunto do Departamento de Ciências Fisiológicas da Universidade Estadual de Londrina – UEL. E-mail: eac@uel.br

Published

2010-05-04

How to Cite

Silva, C. K. da, & Camargo, E. A. (2010). Mechanisms Involved in the Regeneration of Peripheral Nerve Injuries. Saúde E Pesquisa, 3(1). Retrieved from https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/1392

Issue

Section

Artigos de Revisão