Study of the Healing Action of Pereskia aculeate Leaves

  • Claudenice Francisca Providelo Sartor Centro Universitário de Maringá – CESUMAR
  • Valéria do Amaral Centro Universitário de Maringá – CESUMAR
  • Hudson Efrain Theodoro Guimarães Centro Universitário de Maringá – CESUMAR
  • Kellen Nobre de Barros Centro Universitário de Maringá – CESUMAR
  • Daniele Fernanda Felipe Centro Universitário de Maringá – CESUMAR
  • Lucia Elaine Ranieri Cortez Centro Universitário de Maringá – CESUMAR
  • Vanessa Cristina Veltrini Centro Universitário de Maringá – CESUMAR
Keywords: Cactaceae, Pereskia aculeate, Healing Action.

Abstract

Pereskia aculeate, popularly known as “ora-pro-nobis”, belonging to the Cactaceae family, is a climbing shrub, little scientifically studied. In Brazil, it can be found from Bahia to Rio Grande do Sul, it is considered a rustic and persistent plant that grows in different soil types. Popularly, its leaves, besides being used as source of protein, are also used as emollient, where its fruits are used as expectorant and antisyphilitic, without reports of toxicity in the mitigation of inflammatory processes and recovery of skin in cases of skin burn. This study aimed at evaluating the healing capacity of the crude extract of Pereskia aculeate leaves in experimental skin wounds in rats. The methodology used was based on the preparation of the crude extract by soaking in alcohol 92.8% of Pereskia aculeata leaves. After lyophilization of the crude extract, the study of the healing action on skin wounds in rats was performed using 12 Wistar rats. By this study, it was observed that the application of the crude extract of Pereskia aculeata on skin wounds in rats indicates efficacy from the macroscopic point of view. Histologically, the study suggests that the extract has a beneficial effect on the initial healing, no pointing, however, difference in the phase of collagen and epithelium formation. The study pointed out that the crude extract of Pereskia aculeata presents a similar comparative effect from the microscopic point of view, but indicates an improvement in vascular and fibroblastic proliferation and in reepithelialization of animals. Macroscopically, the Pereskia group presented better healing effect.

Author Biographies

Claudenice Francisca Providelo Sartor, Centro Universitário de Maringá – CESUMAR
Orientadora e Docente Doutora do Curso de Farmácia do Centro Universitário de Maringá – CESUMAR. E-mail: claudenice@cesumar.br
Valéria do Amaral, Centro Universitário de Maringá – CESUMAR
Co-Orientadora e Docente Mestre do Curso de Farmácia do Centro Universitário de Maringá – CESUMAR. E-mail: valeriadoamaral@yahoo.com.br
Hudson Efrain Theodoro Guimarães, Centro Universitário de Maringá – CESUMAR
Discente do Curso de Farmácia do Centro Universitário de Maringá – CESUMAR. E-mail: hudson_farmacia@yahoo.com.br
Kellen Nobre de Barros, Centro Universitário de Maringá – CESUMAR
Discente do Curso de Farmácia do Centro Universitário de Maringá – CESUMAR. E-mail: akg0044@hotmail.com
Daniele Fernanda Felipe, Centro Universitário de Maringá – CESUMAR
Docente Mestre do Curso de Farmácia do Centro Universitário de Maringá – CESUMAR. E-mail: danielefelipe@cesumar.br
Lucia Elaine Ranieri Cortez, Centro Universitário de Maringá – CESUMAR
Docente Doutora do Curso de Farmácia do Centro Universitário de Maringá – CESUMAR. E-mail: luciaelaine@cesumar.br
Vanessa Cristina Veltrini, Centro Universitário de Maringá – CESUMAR
Docente do Curso de Odontologia do Centro Universitário de Maringá – CESUMAR. E-mail: vanessa.veltrini@cesumar.br
Published
2010-04-26
Section
Artigos Originais