HEMOGLOBINOPATHY AND ITS PREVALENCE IN BLOOD DONORS

  • Mirian Ueda Yamaguchi Centro Universitário de Maringá - CESUMAR
  • Thaysa Prestes Valer Centro Universitário de Maringá - CESUMAR
  • Marisa Antonia Dodorico Banco de Sangue Dom Bosco
  • Walter Mori Ferreira Banco de Sangue Dom Bosci
Keywords: Blood bank, Blood donors, Types of hemoglobinopathy

Abstract

Hereditary types of anemia are the most common genetic diseases and correspond to a varied complexity group. They may be divided into two groups: thalassemia and hemoglobinopathy. According to WHO, some 270 million people worldwide have genes that determine the presence of abnormal hemoglobins. Studies in Brazil show that approximately 10 million people have the above disease and its distribution involves migratory population movements and miscegenation, according to the regional colonization of the main racial groups. The prevalence of several types of hemoglobinopathy has been identified in blood donors in a blood bank in Maringá PR Brazil which provided a regional estimate of the problem and compared data which already existed in other regions of the country and abroad. Results from the analyses of 78,303 samples revealed high prevalence of anemia in males (1.43%) and in donors from the northeastern and southern regions of Brazil, with 2.51% and 1.35% respectively, and a gradual decrease in the southeastern (1.27%), mid-western (1.19%) and northern (0.85%) regions. Results show that the Brazilian population has various types of prevalence for hemoglobinopathy according to the country’s regions where it is investigated and to the ethnical group involved. The importance of trials for hemoglobinopathy in blood donors should be underscored since the blood receptor is favored by a quality and safe product. The donor may likewise identify a genetic disease which may reveal itself in future progeny.

Author Biographies

Mirian Ueda Yamaguchi, Centro Universitário de Maringá - CESUMAR
Docente do Curso de Biomedicina; Doutora em Ciências Farmacêuticas no Departamento de Biomedicina do Centro Universitário de Maringá – CESUMAR; E-mail: mirianueda@gmail.com.
Thaysa Prestes Valer, Centro Universitário de Maringá - CESUMAR
Pós-graduação em Análises Clínicas - Centro Universitário de Maringá – CESUMAR; E-mail: thaysa_prestes@hotmail.com
Marisa Antonia Dodorico, Banco de Sangue Dom Bosco
Supervisora técnica do Serviço de Hemoterapia do Banco de Sangue Dom Bosco, Maringá/PR; E-mail: marisa@shdb.com.br.
Walter Mori Ferreira, Banco de Sangue Dom Bosci
Diretor Geral do Serviço de Hemoterapia do Banco de Sangue Dom Bosco, Maringá/PR; E-mail: shdb@shdb.com.br.
Published
2011-11-01
Section
Artigos Originais