Vitamin D supplementation attenuates acute inflammatory response

DOI: https://doi.org/10.17765/2176-9206.2020v13n2p377-387
Keywords: Anti-inflammatories, Cholecalciferol, Inflammation, Vitamin D

Abstract

This study evaluated the effects of daily vitamin D supplementation on the acute inflammatory response in experimental model by different phlogistic agents: carrageenan, prostaglandin and dextran. Animals (rats) orally received (gavage) a single dose of vitamin D or daily supplementation for 7, 15 or 30 days prior to paw edema induced. Vitamin D supplementation for 15 and 30 days significantly reduced the carrageenan-induced inflammatory process, which could be at least partially explained by the reduction of tumor necrosis factor α levels (TNFα). Results indicate that vitamin D supplementation may be a useful therapeutic adjuvant for controlling the acute inflammatory process.

Author Biographies

Jessica Faggion Pinheiro de Oliveira, Universidade Estadual de Maringá - UEM
Master´s in Biosciences and Physiopathology; Chemist at the Hospital Universitário Regional de Maringá (HURM), Brazil.
Andrieli Cansi, Universidade Estadual de Maringá - UEM
Master´s in Biosciences and Physiopathology; Chemist in Chapecó SC Brazil.
Bruno Ambrósio Rocha, Centro Universitário de Adamantina
Doctor´s Degree in Pharmaceutical Sciences; Professor of the Department of Medicine at the Centro Universitário de Adamantina SP Brazil.
Ciomar Aparecida Bersani-Amado, Universidade Estadual de Maringá - UEM
Doctor´s Degree Pharmacology; Professor of the Department of Pharmacology and Therapeutics (UEM) and in the Postgraduate Course in Pharmaceutical Sciences at the Universidade Estadual de Maringá (UEM), Brazil.
Silvana Martins Caparroz-Assef, Universidade Estadual de Maringá - UEM
Doctor´s Degree in Cell Biology; Professor of the Department of Pharmacology and Therapeutics (UEM) and in the Postgraduate Course in Biosciences and Physiopathology at the Universidade Estadual de Maringá (UEM), Brazil.

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Published
2020-06-12
Issue
Vol 13 No 2 (2020): abr./jun.
Section
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