Cytotoxic of Carbamide Peroxide in the Root of Meristematic Cells Allium cepa L. - Cytotoxic Potential of Chemicals

  • Ana Paula Perón Faculdade de Apucarana - FAP
  • Fabiano Gaspar Camilloto Faculdade de Apucarana - FAP
  • Verônica Elisa Pimenta Vicentini

Abstract

In the drug research field it is important to assess the potential genotoxic and/or carcinogenic chemical substances. Such assessments are needed to increase the population security that use these compounds. This study aimed to make a cytogenetic assessment of dental bleach carbamide peroxide in the roots of Allium cepa meristematic cells, analyzing it in three concentrations: [1]: 10%, [2]: 20% and [3]: 35% (group-treatment-TR). For this assessment it was established three groups: CO (0h), TR (24h) and RE (24h). It was examined 5.000 cells per group to calculate the average mitotic index of each group, and statistical analysis was performed by Chi-square. From the results, it was found that the tested concentrations of carbamide peroxide caused no statistically significant cytotoxic activity or chromosomal changes in the test system used.

Author Biographies

Ana Paula Perón, Faculdade de Apucarana - FAP
Docente Mestre do Departamento de Ciências Biológicas da Faculdade de Apucarana - FAP. E-mail: anpapegenpes@hotmail.com; ana.peron@fap.com.br
Fabiano Gaspar Camilloto, Faculdade de Apucarana - FAP
Biólogo do Departamento de Ciências Biológicas da Faculdade de Apucarana - FAP. E-mail: zuzumara@bol.com.br
Verônica Elisa Pimenta Vicentini
Docente Doutora do Departamento de Biologia Celular e Genética da Universidade Estadual de Maringá - UEM. E-mail: arbvepv@wnet.com.br
Published
2009-03-20
Section
Artigos Originais