CONTROLLED RELEASE OF THE MEBENDAZOL DRUG FROM A NATURAL POLYMERIC MATRIX

  • Priscila Pereira Silva-Caldeira Centro Federal de Educação Tecnológica de Minas Gerais http://orcid.org/0000-0002-9983-3840
  • Andressa Castro Terto Vilas Boas Centro Federal de Educação Tecnológica de Minas Gerais
  • Bárbara Paiva Machado Centro Federal de Educação Tecnológica de Minas Gerais
  • Diogo Émerson Leite de Carvalho
  • Kláudia Maria Machado Neves Silva UNiversidade Federal de Minas Gerais
DOI: https://doi.org/10.17765/1518-1243.2019v21n1p37-44
Keywords: Drug controlled release, Mebendazole, Alginate

Abstract

The main objectives of controlled drug release system are to minimize the need for toxic doses and to provide better control of the active principle release over time when compared to the conventional form of drug administration. In this work, a controlled release system for the drug mebendazole (MDZ) was prepared using a biodegradable polymeric matrix formed by sodium alginate. This drug has low gastrointestinal absorption due to its low solubility in water. The swelling test and time evaluation of drug release in vitro were performed in a medium that simulates the conditions of the human body. The evaluation of MDZ-doped polymer matrix resistance in the medium showed that it remained for more than 72h in the physiological environment, while the evaluation of the dissolution and release behavior of the MDZ for 8h showed a satisfactory result with a slowly and gradual release of the drug, which indicates the matrix’s potential for being used as a oral device for controlled drug delivery.

Author Biographies

Priscila Pereira Silva-Caldeira, Centro Federal de Educação Tecnológica de Minas Gerais
Docente permanente do Programa de Pós-Graduação Multicêntrico em Química de Minas Gerais no CEFET-MG (PPGMQ-MG/CEFET-MG. Docente permanente do Mestrado interdisciplinar em Tecnologia de Produtos e Processos do CEFET-MG, Brasil
Andressa Castro Terto Vilas Boas, Centro Federal de Educação Tecnológica de Minas Gerais
Graduando em Química Tecnológica Centro Federal de Educação Tecnológica de Minas Gerais, CEFET/MG, Brasil.
Bárbara Paiva Machado, Centro Federal de Educação Tecnológica de Minas Gerais
Graduando em Química Tecnológica Centro Federal de Educação Tecnológica de Minas Gerais, CEFET/MG, Brasil.
Diogo Émerson Leite de Carvalho
Mestrando em Química na Universidade Federal de Ouro Preto (UFOP)
Kláudia Maria Machado Neves Silva, UNiversidade Federal de Minas Gerais
Doutoranda em Engenharia de Produção na Universidade Federal de Minas Gerais (UFMG), Brasil.

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Published
2019-06-24
Issue
Vol 21 No 1 (2019): Temática: Bioquímica, Farmácia e Química
Section
Artigos Originais
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