Diagnóstico repetido de covid-19: influência na modulação autonômica e capacidade funcional de pessoas idosas  : Repeated diagnosis of covid-19: influence on autonomic modulation and functional capacity in older people

Thamyres da Cruz Miranda; Leonardo Hesley Ferraz Durans; Kamilla de Jesus Reis Cruz; Helen Nara da Silva e Silva; Cristiano Teixeira Mostarda; Flávio de Oliveira Pires

doi:10.17765/2176-9206.2025v18e12855

Authors

Thamyres da Cruz Miranda Federal University of Maranhao https://orcid.org/0009-0006-3795-5785
Leonardo Hesley Ferraz Durans Federal University of Maranhão https://orcid.org/0000-0003-1941-1603
Kamilla de Jesus Reis Cruz Federal University of Maranhão https://orcid.org/0009-0001-5969-2035
Helen Nara da Silva e Silva Federal University of Maranhão https://orcid.org/0009-0006-1696-1369
Cristiano Teixeira Mostarda Federal University of Maranhão https://orcid.org/0000-0002-1305-1697
Flávio de Oliveira Pires Federal University of Maranhão https://orcid.org/0000-0002-9497-8928

DOI:

https://doi.org/10.17765/2176-9206.2025v18e12855

Keywords:

COVID-19, Functionality, Older people, Reinfection, Heart rate variability

Abstract

Aim: To analyze the influence of the number of times of diagnosis of covid-19 on autonomic modulation and functional capacity in the older people. Methodology: This is a quantitative cross-sectional study, which included 38 without covid-19 (Control), 25 who had covid-19 once (C1), and 16 infected with covid-19 two or more times (C2+). Anamnesis, anthropometry, blood pressure collection, 6-minute walk test, Time Up and Go and resting electrocardiogram were performed. Data were analyzed by Kolmogorov-Smirnov, followed by 1-way ANOVA and Tukey-Kramer Multiple Comparisons Test, with significance for p?0.05. Results: No differences were found between age, Body Mass Index, systolic and diastolic blood pressure. In terms of autonomic variables, there was a reduction in NN intervals (p=0.04) when comparing C1 and C2+, an increase in LF/HF when comparing C2+ to the control group and C1 (p=0.02), a reduction in SD2 (p=0.01) between C1 and C2+ when compared to the control group, and a reduction in Alpha 1 when comparing the control group to the C1 and C2+ groups (p=0.001). Conclusion: It is suggestive that individuals with a higher number of reinfections may be subject to reduced Heart Rate Variability and increased cardiac autonomic dysfunction.

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Author Biographies

Thamyres da Cruz Miranda, Federal University of Maranhao

Graduated in Physiotherapy (2020) from Ceuma University - São Luís/MA, scholarship category in the University for All Program. Currently a Master's student in the Postgraduate Program in Physical Education at the Federal University of Maranhão - UFMA, Postgraduate student in Exercise Physiology, Preceptor of Outpatient Internship and Nursing of the Physiotherapy Course at Estácio College and Preceptor of the Hydrotherapy Internship of the Physiotherapy Course at the Florence Institute of Higher Education - São Luís/MA. She has a postgraduate degree in Intensive Care. Member of the Laboratory of Cardiovascular Adaptations to Exercise (LACORE/UFMA), with research in the area of Cardiovascular Physiology, Autonomic Control, Aging, Diabetes and Hypertension. He was a Scientific Initiator in the 2019-2020 cycles with research focused on Chronic Non-Communicable Diseases, Cardiovascular Risk and Chronic Cardiorespiratory Diseases.

Leonardo Hesley Ferraz Durans, Federal University of Maranhão

Graduated in Physiotherapy from Ceuma University (2020), scholarship holder in the University for All Program. Master's degree in Adult Health (2023), from the Department of Medicine of the Federal University of Maranhão. Specialist in Exercise Physiology (2024), from UniAmérica - Foz do Iguaçu, Paraná. Postgraduate in Cardiorespiratory Physiotherapy, from Estácio de Sá University. Currently Physiotherapist at the Djalma Marques Municipal Hospital (Socorrão 1), São Luís / MA; Professor and Supervisor of Outpatient, Ward and ICU Internships of the Physiotherapy Course at Estácio University Center - São Luís / MA; Member of the Laboratory of Cardiovascular Adaptations to Exercise (LACORE / UFMA), with research in the area of Cardiovascular Physiology, Autonomic Control, Aging, and Diabetes. He was a Scientific Initiator in the 2018-2019 and 2019-2020 cycles with research focused on Chronic Non-Communicable Diseases, Cardiovascular Risk and Chronic Cardiorespiratory Diseases.

Kamilla de Jesus Reis Cruz, Federal University of Maranhão

Graduated in Nursing (2019) from Ceuma University- São Luís, MA. She has a postgraduate degree in Intensive Care. She is currently a postgraduate student in Public Health and ESF. Member of the Laboratory of Cardiovascular Adaptations to Exercise (LACORE/UFMA).

Helen Nara da Silva e Silva, Federal University of Maranhão

Graduated in General Pharmacy from Faculdade Pitágoras (2020). She has experience in the area of Pharmacy, with an emphasis on clinical pharmacy, pharmaceutical assistance and care, and teaching in professional courses. She has a postgraduate degree in Clinical Pharmacy and Hospital Pharmacy. (2021). She has some Abstracts published in Annals, as well as Book Chapters. She has taught classes in short-term Free Courses, in the area of Health, and Pharmacy. FORMER Member of the Pharmaceutical Clinic League of Faculdade Pitágoras, where she worked as a Minicourse monitor, participated in scientific works as an author, and participated in Social Action Projects. She has a Master's degree in Adult Health, from PPGSAD/UFMA, and is a member of the research group: Laboratory of Cardiovascular Adaptation to Exercise, (LACORE), Professor at SENAC-MA, and administrator/CEO of Nara Farma.

Cristiano Teixeira Mostarda, Federal University of Maranhão

He has a degree in Physical Education from the City University of São Paulo (2001), Specialist in Physiology (UNIFMU), Masters and Doctorate in Sciences from UNIFESP (2002-2006- Department of Nephrology). He was a Tutor in the Multiprofessional Residency of the President Dutra Hospital in São Luis Maranhão. He has experience in the area of Physiology, with an emphasis on physical training and cardiovascular control, where he carried out several scientific works at the Heart Institute (INCOR / FMUSP). He has experience in Tutoring in the Specialization course in Family Health - Mais Médicos Program (Open University of SUS, UNASUS-UFMA, Brazil). He is currently Adjunct Professor at the Federal University of Maranhão (UFMA), where he teaches the subjects of Exercise Physiology and Physical Activity and Aging; Teaches the subjects of Anatomy, Emergency Aid and Measurements and Assessment in Physical Education for the PARFOR program (National Plan for the Training of Basic Education Teachers); Professor of the specialization course in Bodybuilding and Sports Medicine at UFMA; Permanent Professor of the Master's Program in Adult and Child Health (UFMA), Permanent Professor and Vice Coordinator of the Postgraduate Program in Physical Education UFMA (PPGEF-UFMA), Permanent Professor of the Postgraduate Program in Biotechnology (RENORBIO - CCBS- UFMA). Professor and advisor at the Center for Renal Disease Prevention (Multiprofessional Residency at Hospital Presidente Dutra), Professor at the Center for Rehabilitation in Cardiopneumology. (Hospital Presidente Dutra) Coordinator of the Laboratory of Cardiovascular Adaptations to Exercise (LACORE).

Flávio de Oliveira Pires, Federal University of Maranhão

He is currently a Professor at the Federal University of Maranhão (UFMA), with a degree in Physiotherapy from the Faculty of Medical Sciences of Minas Gerais (1997), a Master's degree in Physical Education from the Federal University of Minas Gerais (2002) and a PhD in Biotechnology from the Federal University of Maranhão (2021). At UFMA, he is an Assistant Professor B - level 002 of the subjects: Anatomy Applied to Physical Education and Biomechanics and Kinesiology Applied to Physical Education for the Physical Education courses and Professor of the Seminar in Biomechanics in the Stricto Senso Postgraduate (Master's) in Physical Education of this institution. He has experience since 2000 in Undergraduate and Postgraduate courses for the Physiotherapy and Physical Education courses, working mainly in the following subjects: Pathokinesiology, Kinesiotherapy, Anatomy, Biomechanics, Kinesiology, Sports Injuries, Traumatology and Sports, and Flexibility Training. In the Postgraduate course, research is carried out on the following topics: study of pain, validation and reliability of biomechanical functional tests in people with pain and musculoskeletal disorders, as well as validation and reliability of questionnaires and instruments for measuring pain.

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