Impact of the rs9939609 polymorphism of the FTO gene on obesity in a brazilian population

Bruna Santos Tommasi; Eduarda de Souza Belisário; Daniela  Batista de Castro; Bianca Prandi Campagnaro; Rafaela Aires

doi:10.17765/2176-9206.2026v19e13527

Autores

Bruna Santos Tommasi Vila Velha University https://orcid.org/0009-0008-8688-2302
Eduarda de Souza Belisário Universidade Vila Velha https://orcid.org/0000-0002-6376-0096
Daniela Batista de Castro Universidade Vila Velha https://orcid.org/0009-0009-9797-1260
Bianca Prandi Campagnaro Universidade Vila Velha https://orcid.org/0000-0002-9023-4892
Rafaela Aires Vila Velha University (UVV) https://orcid.org/0000-0002-9532-9401

DOI:

https://doi.org/10.17765/2176-9206.2026v19e13527

Palavras-chave:

polimorfismo rs9939609, antropometria, Adiposidade, Genetic predisposition

Resumo

O objetivo foi investigar a associação entre o polimorfismo rs9939609 do gene FTO e a obesidade em indivíduos da Grande Vitória, Espírito Santo, Brasil. Estudo transversal com 47 participantes, nos quais foram avaliadas medidas antropométricas (IMC, circunferência da cintura e razão cintura-altura). O DNA genômico foi extraído pelo método Salting Out e o polimorfismo rs9939609 foi genotipado por PCR em tempo real. Participantes com IMC>25 apresentaram medidas antropométricas significativamente maiores (p <0,0001). No entanto, não houve diferença na distribuição genotípica do rs9939609 entre os grupos (p = 0,5522), nem associação entre genótipos e parâmetros antropométricos (p >0,05). O polimorfismo rs9939609 do FTO não apresentou associação significativa com a obesidade, sugerindo a influência de outros fatores genéticos e ambientais. Estudos com amostras maiores e análise de interações gene-ambiente são recomendados.

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Biografia do Autor

Bruna Santos Tommasi, Vila Velha University

Graduada em Nutrição pela Universidade de Vila Velha (UVV). Laboratório Tommasi Vitória, Brasil, Av. Américo Buaiz, 200, Enseada do Suá, CEP: 29050-902 - Telefone: 27 3182-1055, Vitória, ES, Brasil - Telefone: +55 (27) 3421-2001.

Eduarda de Souza Belisário, Universidade Vila Velha

Doutoranda em Ciências Farmacêuticas na Universidade de Vila Velha (UVV). Graduada em Fisioterapia pela Universidade de Vila Velha (UVV). Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade de Vila Velha (UVV), Brasil, Av. Comissário José Dantas de Melo, n°21, CEP: 29102-920, Boa Vista, Vila Velha, ES, Brasil - Telefone: +55 (27) 3421-2001.

Daniela Batista de Castro, Universidade Vila Velha

Mestre em Ciências Farmacêuticas pela Universidade de Vila Velha (UVV). Graduada em Enfermagem pela Universidade de Vila Velha (UVV). Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade de Vila Velha (UVV), Brasil, Av. Comissário José Dantas de Melo, n°21, CEP: 29102-920, Boa Vista, Vila Velha, ES, Brasil - Telefone: +55 (27) 3421-2001.

Bianca Prandi Campagnaro, Universidade Vila Velha

Doutora em Ciências Fisiológicas pela Universidade Federal do Espírito Santo (UFES). Graduado em Ciências Biológicas pela Universidade Federal do Espírito Santo (UFES). Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade de Vila Velha (UVV), Brasil, Av. Comissário José Dantas de Melo, n°21, CEP: 29102-920, Boa Vista, Vila Velha, ES, Brasil - Telefone: +55 (27) 3421-2001.

Rafaela Aires, Vila Velha University (UVV)

Doutora em Ciências Fisiológicas pela Universidade Federal do Espírito Santo (UFES). Graduada em Fisioterapia pela Universidade Federal do Espírito Santo (UFES). Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade de Vila Velha (UVV), Brasil, Av. Comissário José Dantas de Melo, n°21, CEP: 29102-920 Boa Vista, Vila Velha, ES, Brasil - Telefone: +55 (27) 3421-2001. Correspondência para: R. AIRES. E-mail: [email protected].

Referências

1. Garcez, A., Dias-da-Costa, J. S., Souza de Bairros, F., & Anselmo Olinto, M. T. Body Mass Index and Prevalence of Obesity in Brazilian Adult Women: Temporal Comparison of Repeated Population-Based Cross-Sectional Surveys. J Obes. 2024;2024:9950895. doi: https://doi.org/10.1155/2024/9950895.

2. Lan X, Sulaiman N. Public Policies on Obesity: A Literature Review of Global Challenges and Response Strategies. Cureus. 2024;16(6):e62758. doi: https://doi.org/10.7759/cureus.62758.

3. NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in underweight and obesity from 1990 to 2022: A pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet. 2024;403(10431):1027-50. doi: https://doi.org/10.1016/S0140-6736(23)02750-2.

4. GBD 2021 Adult BMI Collaborators. Global, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet. 2025;405(10481):813-38. doi: https://doi.org/10.1016/S0140-6736(25)00355-1.

5. Emmerich, Samuel D., Fryar, Cheryl D., Stierman, Bryan, Ogden, Cynthia L. Obesity and Severe Obesity Prevalence in Adults: United States, August 2021-August 2023. NCHS Data Brief. 2024;(508). doi: https://doi.org/10.15620/cdc/159281.

6. Diamantis, D.V., Karatzi, K., Kantaras, P., Liatis, S., Iotova, V., Bazdraska, Y., et al. Prevalence and Socioeconomic Correlates of Adult Obesity in Europe: The Feel4Diabetes Study. Int J Environ Res Public Health. 2022;19(19):12572. doi: https://doi.org/10.3390/ijerph191912572.

7. Tham, K. W., Abdul Ghani, R., Cua, S. C., Deerochanawong, C., Fojas, M., Hocking, S., et al. Obesity in South and Southeast Asia-A new consensus on care and management. Obes Rev. 2023;24(2):e13520. doi: https://doi.org/10.1111/obr.13520.

8. Estivaleti JM, Guzman-Habinger J, Lobos J, Azeredo CM, Claro R, Ferrari G, et al. Time trends and projected obesity epidemic in Brazilian adults between 2006 and 2030. Sci Rep. 2022;12(1):12699. doi: https://doi.org/10.1038/s41598-022-16934-5.

9. Powell-Wiley TM, Poirier P, Burke LE, Després JP, Gordon-Larsen P, Lavie CJ, et al. Obesity and Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2021;143(21):e984-e1010. doi: https://doi.org/10.1161/CIR.0000000000000973.

10. Scully T, Ettela A, LeRoith D, Gallagher EJ. Obesity, Type 2 Diabetes, and Cancer Risk. Front Oncol. 2021;10:615375. doi: https://doi.org/10.3389/fonc.2020.615375.

11. Abbade EB. The cost of obesity and related NCDs in Brazil: An analysis of hospital admissions, disability retirement benefits, and statutory sick pay. Public Health. 2024 Dec;237:184-92. doi: https://doi.org/10.1016/j.puhe.2024.10.006.

12. Abdelaal M, le Roux CW, Docherty NG. Morbidity and mortality associated with obesity. Ann Transl Med. 2017 Apr; 5(7):161. doi: https://doi.org/10.21037/atm.2017.03.107.

13. Lin X, Li H. Obesity: Epidemiology, Pathophysiology, and Therapeutics. Front Endocrinol (Lausanne). 2021 Sep 6;12:706978. doi: https://doi.org/10.3389/fendo.2021.706978.

14. Monda A, de Stefano?MI, Villano?I, Allocca?S, Casillo?M, Messina?A, et al. Ultra-Processed Food Intake and Increased Risk of Obesity: A Narrative Review. Foods. 2024 Aug 21;13(16):2627. doi: https://doi.org/10.3390/foods13162627.

15. Magno FCCM, Guaraná HC, Fonseca ACP, Cabello GMK, Carneiro JRI, Pedrosa AP, et al. Influence of FTO rs9939609 polymorphism on appetite, ghrelin, leptin, IL6, TNF? levels, and food intake of women with morbid obesity. Diabetes Metab Syndr Obes. 2018 May 14;11:199-207. doi: https://doi.org/10.2147/DMSO.S154978.

16. Huang C, Chen W, Wang X. Studies on the fat mass and obesity-associated (FTO) gene and its impact on obesity-associated diseases. Genes Dis. 2022 May 6;10(6):2351-65. doi: https://doi.org/10.1016/j.gendis.2022.04.014.

17. Ursu RI, Badiu C, Cucu N, Ursu GF, Cr?ciunescu I, Severin E, et al. The study of the rs9939609 FTO gene polymorphism in association with obesity and the management of obesity in a Romanian cohort. J Med Life. 2015 Apr-Jun;8(2):232-8. Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC4392093/.

18. Piwonska AM, Cicha Mikolajczyk A, Sobczyk Kopcio? A, Piwonski J, Drygas W, Kwasniewska M, et al. Independent association of FTO rs9939609 polymorphism with overweight and obesity in Polish adults. Results from the representative population-based WOBASZ study. J Physiol Pharmacol. 2022;73(3). doi: https://doi.org/10.26402/jpp.2022.3.07.

19. Mehrdad M, Fardaei M, Fararouei M. The association between FTO rs9939609 gene polymorphism and anthropometric indices in adults. J Physiol Anthropol. 2020 May 12;39(1):14. doi: https://doi.org/10.1186/s40101-020-00224-y.

20. Zhao NN, Dong GP, Wu W. FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis. World J Pediatr. 2019;15(4):382-9. doi: https://doi.org/10.1007/s12519-019-00254-2.

21. Kilpeläinen TO, Qi L, Brage S, Sharp SJ, Sonestedt E, Demerath E, et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med. 2011;8(11):e1001116. doi: https://doi.org/10.1371/journal.pmed.1001116.

22. Wang D, Wu Z, Zhou J, Zhang X. Rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene and metabolic syndrome susceptibility in the Chinese population: a meta-analysis. Endocrine. 2020 Aug;69(2):278-85. doi: https://doi.org/10.1007/s12020-020-02280-x.

23. Barrea L, Annunziata G, Bordoni L, Muscogiuri G, Colao A, Savastano S, et al. Nutrigenetics-personalized nutrition in obesity and cardiovascular diseases. Int J Obes Suppl. 2020 Jul;10(1):1-13. doi: https://doi.org/10.1038/s41367-020-0014-4.

24. Corrêa TAF, Quintanilha BJ, Norde MM, Pinhel MAS, Nonino CB, Rogero MM, et al. Nutritional genomics, inflammation and obesity. Arch Endocrinol Metab. 2020 May-Jun;64(3):205-22. doi: https://doi.org/10.20945/2359-3997000000255.

25. Kiani AK, Bonetti G, Donato K, Carlino E, Fargnoli MC, Biondi ML, et al. Polymorphisms, diet and nutrigenomics. J Prev Med Hyg. 2022 Oct 17;63(2 Suppl 3):E125-41. doi: https://doi.org/10.15167/2421-4248/jpmh2022.63.2S3.2754.

26. Garcia CAB, Meira KC, Souza AH, de Oliveira LFA, Rocha IS, dos Santos VM, et al. Obesity and associated factors in Brazilian adults: systematic review and meta-analysis of representative studies. Int J Environ Res Public Health. 2024 Aug 2;21(8):1022. doi: https://doi.org/10.3390/ijerph21081022.

27. Li H, Kilpeläinen TO, Liu C, Paananen J, Kuusisto J, Laakso M, et al. Variants in the Fat Mass and Obesity-Associated (FTO) Gene Are Not Associated With Obesity in a Chinese Han Population. Diabetes. 2007 Oct 24;57(1):264-8. doi: https://doi.org/10.2337/db07-1130.

28. Solak M, Gurel A, Kucukali CI, Yilmaz M, Karadeniz M, Onat AM, et al. Association of obesity with rs1421085 and rs9939609 polymorphisms of FTO gene. Mol Biol Rep. 2014 Jul 30;41(11):7381-6. doi: https://doi.org/10.1007/s11033-014-3627-2.

29. Pereira Filho B. A ação dos polimorfismos de nucleotídeo único (SNPs) sobre o gene FTO, sua relevância e influência na obesidade: levantamento cienciométrico. Arq Ciênc Saúde UNIPAR. 2021 Mar 15;25(1). ISSN 1982-114X. Link: https://revistas.unipar.br/index.php/saude/article/view/7906/4074.

30. Rodrigues LS. Association between the FTO gene polymorphism and obesity in Brazilian adolescents from the Northeast region. J Pediatr. 2019 Jul.

31. Ling C, Rönn T. Epigenetics in human obesity and type 2 diabetes. Cell Metab. 2019 May 7;29(5):1028-44. doi: https://doi.org/10.1016/j.cmet.2019.03.009.

32. Sonestedt E, Ericson U, Gullberg B, Hellstrand S, Wirfält E, Hedblad B, et al. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr. 2009 Sep 2;90(5):1418-25. doi: https://doi.org/10.1016/j.jped.2019.05.006.

33. Danaher J. High intensity exercise downregulates FTO mRNA expression during the early stages of recovery in young males and females. Nutr Metab. 2020 Aug 17;17(1). doi: https://doi.org/10.1186/s12986-020-00489-1.

34. Grazioli E, Dimauro I, Mercatelli N, Caporossi D, Farì G, Sabatini S, et al. Physical activity in the prevention of human diseases: role of epigenetic modifications. BMC Genomics. 2017;18(Suppl 8):802. doi: https://doi.org/10.1186/s12864-017-4193-5.

35. Abraham MJ, El Sherbini A, El-Diasty M, Abuelezz SA, Abdulghani HM, Fouad HE, et al. Restoring epigenetic reprogramming with diet and exercise to improve health-related metabolic diseases. Biomolecules. 2023;13(2):318. doi: https://doi.org/10.3390/biom13020318.

36. Xiang L, Wu H, Pan A, Chen Z, Hu FB, Liu Y, et al. FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis. Am J Clin Nutr. 2016;103(4):1162-70. doi: https://doi.org/10.3945/ajcn.115.123448.

37. do Nascimento GA, Teixeira MD, Furtado-Alle L, Leal RF, Mota JF, Ribeiro AM, et al. FTO rs9939609 A allele influences anthropometric outcome in response to dietary intervention, but not in response to physical exercise program. Eur J Nutr. 2019;58(1):325-34. doi: https://doi.org/10.1007/s00394-017-1596-7.