Impact of the rs9939609 polymorphism of the FTO gene on obesity in a brazilian population

Bruna Santos Tommasi; Eduarda de Souza Belisário; Daniela  Batista de Castro; Bianca Prandi Campagnaro; Rafaela Aires

doi:10.17765/2176-9206.2026v19e13527

Authors

Bruna Santos Tommasi Universidade Vila Velha https://orcid.org/0009-0008-8688-2302
Eduarda de Souza Belisário Vila Velha University https://orcid.org/0000-0002-6376-0096
Daniela Batista de Castro Vila Velha University https://orcid.org/0009-0009-9797-1260
Bianca Prandi Campagnaro Vila Velha University https://orcid.org/0000-0002-9023-4892
Rafaela Aires Vila Velha University (UVV) https://orcid.org/0000-0002-9532-9401

DOI:

https://doi.org/10.17765/2176-9206.2026v19e13527

Keywords:

rs9939609 polymorphism, anthropometry, Adiposity, Predisposição genética

Abstract

The objective of this study was to investigate the association between the rs9939609 polymorphism of the FTO gene and obesity in individuals from the Greater Vitória region, Espírito Santo, Brazil. This was a cross-sectional study involving 47 participants in whom anthropometric measurements were assessed, including body mass index (BMI), waist circumference, and waist-to-height ratio. Genomic DNA was extracted using the Salting Out method, and the rs9939609 polymorphism was genotyped by real-time PCR. Participants with BMI > 25 presented significantly higher anthropometric measurements (p < 0.0001); however, there was no difference in the genotypic distribution of rs9939609 between groups (p = 0.5522), nor was there an association between genotypes and anthropometric parameters (p > 0.05). The rs9939609 polymorphism of the FTO gene showed no significant association with obesity, suggesting the influence of other genetic and environmental factors, and studies with larger sample sizes and analyses of gene–environment interactions are recommended

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Author Biographies

Bruna Santos Tommasi, Universidade Vila Velha

Graduated in Nutrition from Vila Velha University (UVV). Tommasi Vitória Laboratory, Brazil, Av. Américo Buaiz, 200, Enseada do Suá, CEP: 29050-902 - Telephone: 27 3182-1055, Vitória, ES, Brazil - Telephone: +55 (27) 3421-2001.

Eduarda de Souza Belisário, Vila Velha University

PhD student in Pharmaceutical Sciences at Vila Velha University (UVV). Graduated in Physical Therapy from Vila Velha University (UVV). Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Brazil, Av. Comissário José Dantas de Melo, n°21, CEP: 29102-920 Boa Vista, Vila Velha, ES, Brazil - Telephone: +55 (27) 3421-2001.

Daniela Batista de Castro, Vila Velha University

Master's student in Pharmaceutical Sciences at Vila Velha University (UVV). Graduated in Nursing from Vila Velha University (UVV). Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Brazil, Av. Comissário José Dantas de Melo, n°21, CEP: 29102-920 Boa Vista, Vila Velha, ES, Brazil - Telephone: +55 (27) 3421-2001.

Bianca Prandi Campagnaro, Vila Velha University

Ph.D. in Physiological Sciences from University of Espírito Santo (UFES). Graduated in Biological Sciences from Federal University of Espírito Santo (UFES). Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Brazil, Av. Comissário José Dantas de Melo, n°21, CEP: 29102-920 Boa Vista, Vila Velha, ES, Brazil - Telephone: +55 (27) 3421-2001.

Rafaela Aires, Vila Velha University (UVV)

Ph.D. in Physiological Sciences from Federal University of Espírito Santo (UFES). Graduated in Physical Therapy from Federal University of Espírito Santo (UFES). Pharmaceutical Sciences Graduate Program, Vila Velha University (UVV), Brazil, Av. Comissário José Dantas de Melo, n°21, CEP: 29102-920 Boa Vista, Vila Velha, ES, Brazil - Telephone: +55 (27) 3421-2001. Correspondence to: R. AIRES. E-mail: [email protected].

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