Suplementação com Vitamina D atenua a resposta inflamatória aguda

Palavras-chave: Anti-inflamatórios, Colecalciferol, Inflamação, Vitamina D

Resumo

Este estudo avaliou os efeitos da suplementação diária de vitamina D na resposta inflamatória aguda em modelo experimental por diferentes agentes flogísticos: carragenina, prostaglandina e dextrana. Os animais (ratos) receberam por via oral (gavagem), dose única de vitamina D ou suplementação diária durante 7, 15 ou 30 dias antes da indução do edema de pata. A suplementação com vitamina D por 15 e 30 dias reduziu significativamente o processo inflamatório induzido por carragenina, o que poderia ser explicado, pelo menos parcialmente, pela redução dos níveis de fator de necrose tumoral α (TNFα). Os resultados indicam que a suplementação de vitamina D pode ser um útil adjuvante terapêutico para o controle do processo inflamatório agudo.

Biografia do Autor

Jessica Faggion Pinheiro de Oliveira, Universidade Estadual de Maringá
Mestre em Biociências e Fisiopatologia, Farmacêutica do Hospital Universitário Regional de Maringá (HURM), Brasil
Andrieli Cansi, Universidade Estadual de Maringá - UEM
Mestre em Biociências e Fisiopatologia, Farmacêutica do Município de Chapecó - SC, Brasil.
Bruno Ambrósio Rocha, Centro Universitário de Adamantina
Doutor em Ciências Farmacêuticas, Professor do Departamento de Medicina do Centro Universitário de Adamantina - SP, Brasil
Ciomar Aparecida Bersani-Amado, Universidade Estadual de Maringá - UEM
Doutora em Farmacologia, Professora Associada Permanente do Departamento de Farmacologia e Terapêutica - UEM, e do Programa de Pós-Graduação em Ciências Farmacêuticas na Universidade Estadual de Maringá (UEM), Brasil.
Silvana Martins Caparroz-Assef, Universidade Estadual de Maringá - UEM
Doutora em Biologia Celular, Professora Associada Permanente do Departamento de Farmacologia e Terapêutica - UEM, e do Programa de Pós-Graduação em Biociências e Fisiopatologia na Universidade Estadual de Maringá (UEM), Brasil.

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Publicado
2020-06-12
Seção
Artigos Originais