Juvenile stress of short frequency and intensity does not affect rats´ brain white matter

DOI: https://doi.org/10.17765/2176-9206.2022v15n2.e10469
Keywords: Corpus callosum, Immobilization, Myelin, Oligodendrocytes, Psychologic stress

Abstract

The current study evaluates the lasting effects of two types of stress on the corpus callosum (CC). Forty-two male Wistar rats were randomly divided into three groups: Control Group (CG), Physical Stress (FS, immobilization) and Psychological Stress (PS, exposure to predators). Stress procedures occurred for three consecutive days at the juvenile stage (P25-P27) and analyzed at the adult age (P74); brains were retrieved and processed by Klüver-Barrera technique and sections were analyzed by morphometry. Results showed that there were no changes in the general aspects such as animal weight, and in the histological aspects such as CC thickness and quantity of the region´s glia nuclei. Current research suggests that the lasting effects of both models of juvenile stress of short frequency (3 days) and intensity (90 minutes/FS and 20 minutes/PS) were neither detrimental nor protective, featuring a positive adaptation.

Author Biographies

Vivian Fuguhara de Lima, Universidade Estadual de Maringá - UEM
Student of Biomedicine at the State University of Maringá (UEM), Department of Clinical Analysis and Biomedicine (DAB), Maringá (PR), Brazil.
Kathia Terumi Kato, State University of Maringá
Student of Biomedicine at the State University of Maringá (UEM), Department of Clinical Analysis and Biomedicine (DAB), Maringá (PR), Brazil.
Letícia Alexandrino Barilli, State University of Maringá
Student of Biomedicine at the State University of Maringá (UEM), Department of Clinical Analysis and Biomedicine (DAB), Maringá (PR), Brazil.
Silvana Regina de Melo, State University of Maringá
PhD Professor at the Department of Morphological Sciences (DCM) at the State University of Maringá (UEM), Maringá (PR), Brazil.

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Published
2022-04-29
Issue
Vol 15 No 2 (2022): abr./jun.
Section
Artigos Originais

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