Genetic variability of sars-cov-2: an analysis of mutations in mhc-i and ii epitopes and impacts on vaccination by AZD1222 in the brazilian population

Variabilidade genética do sars-cov-2: uma análise de mutações em epítopos de mhc-i e ii e impactos frente à vacinação por AZD1222 na população brasileira

Authors

DOI:

https://doi.org/10.17765/2176-9206.2024v17n4.e12563

Keywords:

Epitopes, SARS-CoV-2, Vaccination, Variability

Abstract

The study aimed to analyze mutations in MHC-I and II epitopes in the face of vaccination with AZD1222 in Brazil. Mutations were identified in six epitopes, some of which decreased their immunogenicity, such as NYNYRYRLF of MHC-I, from 783 to 171. This suggests a possible reduction in the vaccine's efficacy against mutant variants of the virus. The research highlights the importance of adapting immunization strategies to deal with emerging SARS-CoV-2 mutations. It also highlights the need to monitor the genetic variability of the virus and develop updated vaccines to combat the pandemic. These results also emphasize the importance of understanding the mutations of the virus to correlate with its evolution and virulence, providing valuable insights for the control of COVID-19.

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Author Biographies

Ana Maria Barbosa Neves, Federal University of Paraíba

Graduated in Biological Sciences, Bachelor's degree from the Federal Institute of Education, Science and Technology of Paraíba (IFPB). Master's student in Cellular and Molecular Biology from the Federal University of Paraíba (UFPB). Member of the Research Groups: Studies in Microbiology Applied to Human and Animal Health - GEMASHA and Study Group in Education, Culture, Human Rights and Citizenship - GECDHC.

Waléska Faustino Rodrigues, Federal Institute of Paraíba

I have a Bachelor's degree in Electrical Engineering from the Instituto Federal da Paraíba - Campus João Pessoa. I am an active member of the Signal Processing Research Group (GPDS) and the Telecommunications and Applied Electromagnetism Group (GTEMA). In addition, I have the honor of chairing the Women in Engineering (WIE) affinity group of the IEEE branch of IFPB-JP and an active member of IEEE. I have a strong interest in the areas of telecommunications and electronics.

Kamilly Flávia Carvalho dos Santos, Federal Institute of Paraíba

Studying for a Bachelor's Degree in Electrical Engineering at the Instituto Federal da Paraíba - Campus João Pessoa. Electronics Technician also from IFPB. Member of the IEE Branch of IFPB-JP, being president of the branch and member of the IEE affinity group WIE (Women in Engineering). Participant of the Telecommunications and Applied Electromagnetism Group (GTEMA) with research in the area of ​​microstrip antennas. Participant of the Digital Signal Processing Research Group (GPDS) with research in the area of ​​mathematical modeling of the arterial communication system. Research and development on Microstrip Antennas and Digital Signal Processing using computational methods.

Maria Angélica Ramos da Silva, Federal Institute of Paraíba

She holds a degree (bachelor's and undergraduate degrees) in Biological Sciences from the Federal University of Paraíba (2004), and a master's and doctorate in Genetics from the Federal University of Pernambuco (2012). She completed an international internship during her doctorate at the Federico II University in Naples, Italy, in 2011. Later, she was a research fellow at the Federal University of Pernambuco (2012 - 2014) during her postdoctoral period. She is currently a professor of basic, technical and technological education at the Federal Institute of Education, Science and Technology of Paraíba, Cabedelo campus, where she teaches the Bachelor's Degree in Biological Sciences and Fisheries Resources Technician courses. She currently coordinates the Pedagogical Residency Program, in the Biology subproject. She is the coordinator of the Study and Research Group in Microbiology Applied to Human and Animal Health (GEMASHA). He has experience in the area of ​​Genetics, with an emphasis on Molecular and Microorganism Genetics, working mainly on topics related to the investigation of the biology and diversity of viruses, development of diagnostic tests and antimicrobial agents.

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Published

2024-12-03

How to Cite

Barbosa Neves, A. M., Faustino Rodrigues, W., Carvalho dos Santos, K. F. ., & Ramos da Silva, M. A. . (2024). Genetic variability of sars-cov-2: an analysis of mutations in mhc-i and ii epitopes and impacts on vaccination by AZD1222 in the brazilian population: Variabilidade genética do sars-cov-2: uma análise de mutações em epítopos de mhc-i e ii e impactos frente à vacinação por AZD1222 na população brasileira. Saúde E Pesquisa, 17(4), e12563. https://doi.org/10.17765/2176-9206.2024v17n4.e12563

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Vol. 17 No. 4 (2024): oct./dec.

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