Marcadores inflamatórios e magnésio séricos em pacientes com migrânea - um estudo caso-controle: Inflammatory markers and serum magnesium in patients with migraine - a case-control study

Franciluz Morais Bispo; Arquimedes Cavalcante Cardoso

doi:10.17765/2176-9206.2025v18e12609

Authors

Franciluz Morais Bispo Universidade Federal do Piauí https://orcid.org/0000-0002-2825-194X
Arquimedes Cavalcante Cardoso Federal University of Piauí https://orcid.org/0000-0001-9546-805X

DOI:

https://doi.org/10.17765/2176-9206.2025v18e12609

Keywords:

Neurogenic Inflammation, Magnesium, Migraine

Abstract

Migraine is a ubiquitous condition. A higher inflammatory level agents trigger trigeminal nerves activation and neuropeptides release and cause neuroinflammation. Magnesium deficiency plays a role stimulating spreading cortical depression. This study aims to determine the correlation among inflammatory-markers, magnesium and migraine. METHODS: Prospective, case-control, quantitative. Divided into 2 groups: Case and Control. Included healthy people between 18 to 60 years. A form with anthropometric, socioeconomic and clinical data and Magnesium and inflammatory-markers serum were filled. Analyzed using SPSS. RESULTS: Groups were significantly different in migraine family history and insomnia. Magnesium [Control:1.97±0.16, Case:2.06±0.40; p:0.379], C-Reactive Protein [Control:4.40±3.66, case:3.17±4.61, p:0.088], ESR [Control:7.34±6.71, Case:16.16±13,50, p:<0.00001], LDL-c [Control:98.49±31.33, Case:116.65±38,55, p:0,035], HDL-c [Control:61.45±19,11, Case:50.36±19,04, p:0,005], Ferritin [Control:63.37±64.93, Case:105.34±213,11, p:0,315], Fibrinogen [Control:279.79±93,12, Case:378.32±131.82, p:0,017]. Conclusion: There was a significant correlation among migraine, insomnia and family inheritance. The ratio between migraine and inflammatory-markers was significant for LDL-c, ESR, fibrinogen and HDL-c. In magnesium, no significant differences.

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Author Biographies

Franciluz Morais Bispo, Universidade Federal do Piauí

He has a degree in Medicine from the Federal University of Piauí (2009), specialization in adult neurointensivism from the Sírio-Libanês Hospital (2015) and a medical residency from the Base Hospital of the Federal District (2013). He is currently a NEUROLOGIST at HOSPITAL UNIVERSITARIO DA UFPI, PRECEPTOR OF THE MEDICAL RESIDENCY IN NEUROLOGY at HOSPITAL UNIVERSITARIO DA UFPI, Neurologist at Med Imagem and PRECEPTOR OF THE NEUROLOGY RESIDENCY at Hospital Universitário do Piaui/Ebserh.

Arquimedes Cavalcante Cardoso, Federal University of Piauí

Graduated in Medicine from the Federal University of Piauí (1990), Master in Medical Sciences from the State University of Campinas (2002) and Doctor in Medical Sciences from the State University of Campinas (2007). Assistant physician at the Getúlio Vargas Hospital, acting as Head of the Neurosurgery Service and neurosurgeon providing services to the Piauí Society for the Fight Against Cancer. Associate Professor III of the Department of Specialized Medicine, in the area of Neurology and Medical Ethics of the Medicine course at the Federal University of Piauí. Director of the Health Sciences Center of the Federal University of Piauí. Full Counselor of the Regional Council of Medicine of Piauí. Has experience in the area of Medicine, with emphasis on Neurosurgery, microsurgery, endovascular neurosurgery and surgery of the spine and peripheral nerves.

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