Influência da massa magra e gorda no ângulo de fase de pacientes com distrofia muscular de Duchenne: Influence of lean and fat mass on the phase angle of patients with Duchenne muscular dystrophy

Mariana Angélica de Souza  Leon; Rafael dos Anjos  Aguiar; Ana Cláudia  Mattiello-Sverzut

doi:10.17765/2176-9206.2025v18e12870

Authors

Mariana Angélica de Souza Leon University of Sao Paulo https://orcid.org/0000-0003-4274-1301
Rafael dos Anjos Aguiar Paulista University https://orcid.org/0000-0003-2049-5250
Ana Cláudia Mattiello-Sverzut University of Sao Paulo https://orcid.org/0000-0002-4181-0718

DOI:

https://doi.org/10.17765/2176-9206.2025v18e12870

Keywords:

Duchenne muscular dystrophy, Body Composition, Bioelectrical Impedance, Dystrophyn, phase angle

Abstract

Objective: To realize a narrative review of the literature to explore aspects related to the percentage of lean fat mass (FM) and fat-free mass (FFM) and their relationship with phase angle (PA) in patients with Duchenne muscular dystrophy (DMD). Methods: A literature review was carried out, through a search in health science databases, using the terms Duchenne Muscular Dystrophy; Bioelectrical Impedance, Body Composition. Results: 9 studies met the selection criteria and were included in this review. The data indicate that individuals with DMD have a higher percentage of FM, a lower percentage of FFM and lower PA values than healthy subjects, where the absence of dystrophin results in instability in the muscle membrane and a subsequent decrease in PA. Conclusion:The FFM, MG and AF variables are modified with the progression of DMD, and the relationship between them is not clear. It is suggested that future studies explore the prognostic and therapeutic potential of the use of PA in DMD, correlating it with measures of functional performance and muscle strength.

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Author Biographies

Mariana Angélica de Souza Leon, University of Sao Paulo

Physiotherapist (FMRP-USP, 2012); Master of Science (FMRP-USP, 2014) and PhD in Science (FMRP-USP, 2023). Postgraduate in Palliative Care (Instituto Latinoamericano Pallium, 2017). Coordinator of the multidisciplinary team at the Ribeirão Preto State Hospital (HERibeirão - ONA Accredited Hospital level 3 - Accredited with Excellence) since 2019. Coordinator of the Integrated Humanization Center at HERibeirão since 2016. Coordinator of the "Elderly-Friendly Hospital" project at HERibeirão since 2017 (Hospital with Full certification in this project). Member of the HERibeirão Quality Team, responsible for the Internal Processes front of the institutional Strategic Planning. Member of the "Collective of Hospitals and Santas Casas of the Regional Health Department of region XIII (DRS XIII - Ribeirão Preto) since 2016. Member of the Palliative Care Group of HERibeirão since 2015. Preceptor of the Multiprofessional Residency Program in Cancer Care at HCFMRP-USP. Collaborating professor of the Residency in Palliative Medicine at HCFMRP-USP and of the Specialization course in Adult and Child Neurofunctional Physiotherapy at CEFOR/HCFMRP-USP.

Rafael dos Anjos Aguiar, Paulista University

Graduated in Physiotherapy from Universidade Paulista - Ribeirão Preto, Post-Graduated in the Specialization Program in Adult and Child Neurofunctional Physiotherapy at the Hospital das Clínicas of the Faculty of Medicine of Ribeirão Preto - USP. Throughout my undergraduate studies, I sought to carry out complementary activities, participating in studies in the Anatomy Laboratory, Observatory Internships, Symposiums, Extension Courses and Public Awareness Events. I acted as Class Representative and Monitor in the disciplines of Semiology and Thermo and Phototherapy, assisting teachers during theoretical and practical classes. During my specialization, I worked at different levels of health care, in various fields of activity, such as Wards and Outpatient Clinics in Rehabilitation Centers, as well as Early Stimulation Groups, Orthotics, Prosthetics and Wheelchair Adaptation Workshops. Always seeking to improve my knowledge, to better meet the needs of my patients and promote quality care. Working in healthcare as a Physiotherapist and in the academic environment as an Internship Supervisor, I had the opportunity to improve my technical and interpersonal skills, thus contributing to improving the health and quality of life of my patients, as well as the professional development of undergraduate students.

Ana Cláudia Mattiello-Sverzut, University of Sao Paulo

Graduated in Physiotherapy from UFSCar (1989). Master's degree in Functional and Molecular Biology from IB-UNICAMP (1994). PhD in Experimental and Comparative Pathology from FMRP-USP (1999). Joined FMRP-USP as a professor in 2003. Post-doctorate at the Institute of Sports Medicine Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark (2008-2009). Coordinates the disciplines: Kinesiotherapy, Physiotherapy Applied to Pediatrics and Internship in Pediatric Neurofunctional Physiotherapy. She was General Coordinator of the Integrated Rehabilitation Center (CIR) of the State Hospital linked to HC-FMRP-USP (2019-2023). She is the current Coordinator of the Physiotherapy area at CIR-HE. She is the Coordinator of the Research Committee of CER-HCFMRP-USP. She is a Member of the Editorial Board of the Brazilian Journal Physical Therapy. He has experience in the area of Neurological Physiotherapy (Subareas: Child Neurology, especially neuromuscular diseases). He develops scientific studies with humans, focusing on myopathies, Charcot Marie Tooth disease, spinal muscular atrophy and myelomeningocele, and with animals, analyzing morphology and function of skeletal muscles.

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