Relação do gene TLX1 na patogênese da leucemia linfoblástica aguda de linhagem t (lla-t): Relation of the TLX1 gene in the pathogenesis of T-lineage acute lymphoblastic leukemia (T-ALL)

Marianne Silva Lopes; Evelle Rodrigues Souza; Ag-Anne Pereira Melo de Menezes

doi:10.17765/2176-9206.2025v18e12954

Authors

Marianne Silva Lopes Centro Universitário UniFacid Wyden https://orcid.org/0009-0000-3399-4804
Evelle Rodrigues Souza Centro Universitário UniFacid Wyden https://orcid.org/0009-0007-7199-067X
Ag-Anne Pereira Melo de Menezes Centro Universitário UniFacid Wyden https://orcid.org/0000-0003-2830-990X

DOI:

https://doi.org/10.17765/2176-9206.2025v18e12954

Keywords:

T lineage, gene expression, Leukemia, HOX1

Abstract

T-lineage acute lymphoblastic leukemia (T-ALL) is an aggressive form of leukemia that mainly affects children and adolescents, with challenges in treatment and clinical management. This work investigates the impact of the TLX1/HOX11 gene in the pathogenesis of T-ALL, focusing on molecular alterations, diagnosis and therapeutic implications. Through a literature review (2017-2023), using descriptors such as "T-lineage", "gene expression", "leukemia" and "HOX11", it was observed that TLX1/HOX11 overexpression is associated with a better response to standard chemotherapy regimens, although it presents challenges in disease control. Understanding the role of this gene is crucial to develop targeted therapeutic strategies, aiming at better clinical outcomes and quality of life for patients with T-ALL.

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Author Biographies

Marianne Silva Lopes, Centro Universitário UniFacid Wyden

Biomedicine from the UniFacid University Center and postgraduate student in Hematology and Blood Bank with an emphasis on cytomorphology at the GPI Institute. Monitors the subjects of Microbiology and Basic Immunology, Anatomy of organic systems, Pathology, Clinical Biochemistry. Member of the committee of the UniFacid Academic Center for Biomedicine (CEABI) and the UniFacid Academic League of Biotechnology and the Interdisciplinary Academic League of Pathology of the Bahian School of Medicine and Public Health (EBMSP). She is currently a volunteer Scientific Initiation researcher (PIBIC) with the project entitled: Assessment of the Genotoxic, Cytotoxic and Toxigenic Potential of Prednisone and Hydroxychloroquine extracts used in the treatment of patients with Systemic Lupus Erythematosus (SLE). She also does an extracurricular internship at the Piaui Central Public Health Laboratory.

Evelle Rodrigues Souza, Centro Universitário UniFacid Wyden

Graduating in Biomedicine from Centro Universitário Unifacid Wyden. She is currently Deputy Director of the Academic Center for Biomedicine (CEABI) and Volunteer Scientific Initiation Researcher (PIBIC) with the project entitled Assessment of the Genotoxic, Cytotoxic and Toxicogenic Potential of Prednisone and Hydroxychloroquine extracts used in the treatment of patients with Systemic Lupus Erythematosus ( LES), at Unifacid Wyden.

Ag-Anne Pereira Melo de Menezes, Centro Universitário UniFacid Wyden

He has a degree in Biomedicine and a Degree in Biological Sciences. PhD in Biotechnology / Northeast Biotechnology Network (RENORBIO/UFPI). Master in Pharmaceutical Sciences from the Federal University of Piauí- UFPI. Specialist in Clinical Hematology and Blood Bank and Advanced Interdisciplinary Aesthetic Health. She currently works as a Postgraduate Professor at GPI College and Undergraduate for the Biomedicine, Pharmacy and Physiotherapy course at AVP-AESPI / UNIP and Professor at UNIFACID Wyden for the Biomedicine, Nutrition and Pharmacy course. Member of the Toxicological Genetics Research Laboratory-LAPGENIC/UFPI. Participant in the Translational Physiopharmacology and Preclinical Toxicology research group at UFPI. Experience in clinical analysis, cell culture, molecular biology, toxicological genetics, with an emphasis on mutagenesis and carcinogenesis. Experience in teaching higher education in the disciplines of General Toxicology, Molecular Biology, Basic Immunology, Clinical Immunology, Epidemiology and Public Health, Biochemistry, Parasitology, Blood Bank, Biotechnology, Anate Pharmacology. Works in the lines of research in cell culture and molecular biology, toxicity assessment, cytotoxicity, oxidative and apoptotic activity, toxicological genetics with an emphasis on genotoxicity, mutagenesis and carcinogenesis.

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