Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol

Authors

  • Fabiane Luizetti Centro Universitário de Maringá - CESUMAR
  • Caroline Scilovski Avancini Centro Universitário de Maringá - CESUMAR
  • Jeronimo Perez Vargas Filho Centro Universitário de Maringá - CESUMAR
  • Tatiane Garcia da Silva
  • Mirian Ueda Yamaguchi Centro Universitário de Maringá - CESUMAR

Keywords:

Genotoxicity, Cresol, blood cells, Micronucleus

Abstract

Cresol is a hydrocarbonate and phenol compound used as a highly efficient disinfectant against several bacteria. Cresol has recently been used in experiments in the cure of wounds and tissue recovery. In fact, it features wound healing with neo-vascularization and re-epithelization. Current analysis evaluates the genotoxic effect of cresol in mice’s blood cell by micronucleus test. Sixteen female mice were employed and divided into three groups. The first group was the positive control to which cyclophosphamide at a single dose of 50mg/kg was administered. The second group received a physiological solution 0.9%, as negative control. The third group was treated with cresol. Euthanasia occurred 48 h after treatment and laminas with intracardiac blood were investigated by evaluating 1000 polychromatic erythrocytes for micronucleus counting. Within the concentration tested, cresol is a genotoxic compound that induces alteration in cell DNA and causes the formation of residual micronuclei.

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Author Biographies

Fabiane Luizetti, Centro Universitário de Maringá - CESUMAR

Zootecnista e Médica Veterinária, Mestre, discente do curso de especialização em Análises Clínicas do CESUMAR; e-mail: fabiluizetti@gmail.com

Caroline Scilovski Avancini, Centro Universitário de Maringá - CESUMAR

Farmacêutica, discente do curso de especialização em Análises Clínicas do CESUMAR; e-mail: krolscilovski@hotmail.com

Jeronimo Perez Vargas Filho, Centro Universitário de Maringá - CESUMAR

Discente do curso de Medicina Veterinária do CESUMAR; e-mail: jeronimovargas@hotmail.com

Tatiane Garcia da Silva

Médica Veterinária; E-mail: tati.garcia.veterinaria@gmail.com

Mirian Ueda Yamaguchi, Centro Universitário de Maringá - CESUMAR

Farmacêutica, Doutora, docente do curso de Farmácia, Biomedicina, especialização em Análises Clínicas do Centro Universitário de Maringá - CESUMAR, Mestrado em Promoção da Saúde; e-mail: mirianueda@gmail.com

Published

2012-04-23

How to Cite

Luizetti, F., Avancini, C. S., Vargas Filho, J. P., Silva, T. G. da, & Yamaguchi, M. U. (2012). Genotoxic Effect In Erythrocytes Of Mice Treated Orally With Cresol. Saúde E Pesquisa, 5(3). Retrieved from https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2144

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Section

Artigos Originais