REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2

Authors

  • Ricardo Augusto Leoni De Sousa Universidade Federal de Sergipe
  • Emerson Pardono Universidade Federal de Sergipe

Keywords:

Diabetes Mellitus Type 2, Resisted Exercise, Resistance to Insulin.

Abstract

Diabetes mellitus type 2 (DM2) comprises more than 95% of diabetes cases worldwide. It main characteristic is its resistance to insulin which causes the development of hyperglycemia and hyperinsulinemia. Current study analyzes through a revision of the literature the benefits of resisted exercise in the resistance to insulin and its understanding. The key point in DM2 metabolism and its main causes are the protein kinase B (AKT) and Phosphatidylinositol-3-kinase (PI3-K). Resistance to insulin is associated with defects in the activation of receptors of insulin 1 and 2 and/or low activation of PI3-K and/or the slight displacement of GLUT-4, a transporter of glucose. Its intracellular movement depends on AKT signalization. High intensity RE is capable of promoting a greater phosphorylation of insulin receptors and/or increasing the activity of PI3-K and/or raising the translocation of the main glucose vehicle during physical activity and GLUT-4, by a greater activation of AKT. Intense RE strives against insulin resistance and favors a greater and better functioning of the PI3-K pathway.

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Author Biographies

Ricardo Augusto Leoni De Sousa, Universidade Federal de Sergipe

Mestre em Educação Física pela Universidade Federal de Sergipe - UFS, Aracaju, SE, Brasil

Emerson Pardono, Universidade Federal de Sergipe

Doutor em Educação Física pela Universidade Católica de Brasília – UCB; Docente do Departamento de Educação Física e do programa de Pós-Graduação Stricto-Sensu em Educação Física da Universidade Federal de Sergipe - UFS, Aracaju, SE, Brasil

Published

2014-07-31

How to Cite

De Sousa, R. A. L., & Pardono, E. (2014). REPORT ON THE RESISTANCE TO INSULIN AND THE BENEFITS OF INTENSE EXERCISE IN DIABETES TYPE 2. Saúde E Pesquisa, 7(2). Retrieved from https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/3449

Issue

Section

Promoção da Saúde