Epidemiological analysis of new leprosy cases in an old colony in the State of Minas Gerais (2000-2016)

Authors

DOI:

https://doi.org/10.17765/2176-9206.2020v13n4p871-877

Keywords:

BCG, Leprosy, Mycobacterium leprae

Abstract

The objective of this study was to describe and relate operational classification, BCG vaccination, and gender between new cases of leprosy in the Padre Damião Colony, municipality of Ubá, State of Minas Gerais, from 2000 to 2016. Data were collected from report forms and interviews, totalizing 43 new studied cases. The descriptive analysis indicated the predominance of the female gender, multibacillary form, and vaccinated individuals. Moreover, there was a decrease in the percentage of multibacillary cases in individuals with one or two BCG scars compared to those without scarring. In women with a scar, compared to those without a scar, there was a lower percentage of multibacillary cases. In men, paucibacillary cases were found only in individuals with two scars. Therefore, the BCG vaccine given in 1 dose is related to protection against the multibacillary form in women. In men, the second dose is required for protection against this clinical form.

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Author Biographies

Ingrid Rabite Garcia, Universidade Federal de Viçosa - UFV

Master in Cellular and Structural Biology in the area of concentration Immunoparasitology. PhD student in the Postgraduate Program in Cellular and Structural Biology at the Federal University of Viçosa – UFV, Viçosa (MG), Brazil.

Adriana Maria Rocha Trancoso Santos, Universidade Federal de Viçosa - UFV

PhD in Civil Engineering in the area of concentration Spatial Information (Geoprocessing). Administration Assistant at the Federal University of Viçosa – UFV, Viçosa (MG), Brazil.

Patrícia Feliciano Pereira, Universidade Federal de Viçosa - UFV

PhD in Nutrition Science. Permanent professor of the Graduate Program in Nutrition Science at the Federal University of Viçosa – UFV, Viçosa (MG), Brazil

Eduardo de Almeida Marques da Silva, Universidade Federal de Viçosa - UFV

PhD in Biological Sciences in the area of concentration Protozoan Immunobiology. Permanent professor of the Graduate Program in Cellular and Structural Biology, Department of General Biology, Federal University of Viçosa – UFV, Viçosa (MG), Brazil.

References

Britton WJ, Lockwood DN. Leprosy. Lancet. 2004;363(9416):1209-19.

Organization, W.H., WHO Expert Committee on leprosy: eighth report. 2012. p. 72.

Reibel F, Cambau E, Aubry A. Update on the epidemiology, diagnosis, and treatment of leprosy. Med Mal Infect. 2015;45(9):383-93.

Rodrigues LC, Lockwood D. Leprosy now: epidemiology, progress, challenges, and research gaps. Lancet Infect Dis. 2011;11(6):464-70.

Freitas LR, Duarte EC, Garcia LP. Trends of main indicators of leprosy in Brazilian municipalities with high risk of leprosy transmission, 2001-2012. BMC Infect Dis. 2016;16:472.

Zodpey SP. Protective effect of bacillus Calmette Guerin (BCG) vaccine in the prevention of leprosy: a meta-analysis. Indian J Dermatol Venereol Leprol. 2007;73(2):86-93.

Duthie MS, Balagon MF. Combination chemoprophylaxis and immunoprophylaxis in reducing the incidence of leprosy. Risk Manag Healthc Policy. 2016;9:43-53.

Setia MS, Steinmaus C, Ho CS, Rutherford GW. The role of BCG in prevention of leprosy: a meta-analysis. Lancet Infect Dis. 2006;6(3):162-70.

World Health Organization. Global leprosy update, 2016: accelerating reduction of disesase burden. Wkly Epidemiol Rec. 2017;92(35):501-19.

Campos SSL, Ramon AN, Kerr-Pontes LRS, Heukelbach J. Epidemiologia da hanseníase no município de Sobral, Estado do Ceará-Brasil, no período de 1997 a 2003. Hansenol Int. 2005;30:167-75.

Moreira SC, Batos CJ, Tawil L. Epidemiological situation of leprosy in Salvador from 2001 to 2009. An Bras Dermatol. 2014;89(1):107-17.

Silva ME, de Souza CD, Costa e Silva SP, Costa FM, Carmo RF. Epidemiological aspects of leprosy in Juazeiro-BA, from 2002 to 2012. An Bras Dermatol. 2015;90(6):799-805.

Queiros MI, Ramos ANJ, Alencar CH, Monteiro LD, Sena AL, Barbosa JC. Clinical and epidemiological profile of leprosy patients attended at Ceara, 2007-2011. An Bras Dermatol. 2016;91(3):311-7.

Martins RJ, Carloni ME, Moimaz SA, Garbin CA, Garbin AJ. Sociodemographic and epidemiological profile of leprosy patients in an endemic region in Brazil. Rev Soc Bras Med Trop. 2016;49(6):777-80.

Figueiredo IA, da Silva AA. [Increase in leprosy detection rates in Sao Luis, Maranhao, Brazil, from 1993 to 1998: is the endemic expanding?]. Cad Saude Publica. 2003;19(2):439-45.

Sanches LA, Pittner E, Sanches HF, Monteiro MC. [Detection of new cases of leprosy in the City of Prudentopolis, PR: the analysis from 1998 to 2005]. Rev Soc Bras Med Trop. 2007;40(5):541-5.

Goulart IM, Arbex GL, Carneiro MH, Rodrigues MS, Gadia R. [Adverse effects of multidrug therapy in leprosy patients: a five-year survey at a Health Center of the Federal University of Uberlandia]. Rev Soc Bras Med Trop. 2002;35(5):453-60.

Miranzi Sde S, Pereira LH, Nunes AA. [Epidemiological profile of leprosy in a Brazilian municipality between 2000 and 2006]. Rev Soc Bras Med Trop. 2010;43(1):62-7.

Imbiriba EB, Hurtado-Guerrero JC, Garnelo L, Levino A, Cunha Mda G, Pedrosa V. Epidemiological profile of leprosy in children under 15 in Manaus (Northern Brazil), 1998-2005. Rev Saude Publica. 2008;42(6):1021-6.

Amaral EP, Lana FC. [Spacial analysis of Leprosy in the microregion of Almenara, MG, Brazil]. Rev Bras Enferm. 2008;61 Spec No:701-7.

Ministério da Saúde (BR). Diretrizes para vigilância, atenção e eliminação da hanseníase como problema de saúde pública 2016. [Available from: http://www.saude.pr.gov.br/arquivos/File/DiretrizesdoManualTecnicoOperacionaldeHanseniase.pdf].

Correa Rda G, Aquino DM, Caldas Ade J, Amaral DK, Franca FS, Mesquita ER. Epidemiological, clinical, and operational aspects of leprosy patients assisted at a referral service in the state of Maranhao, Brazil. Rev Soc Bras Med Trop. 2012;45(1):89-94.

Duthie MS, Gillis TP, Reed SG. Advances and hurdles on the way toward a leprosy vaccine. Hum Vaccin. 2011;7(11):1172-83.

Goulart IM, Bernardes Souza DO, Marques CR, Pimenta VL, Goncalves MA, Goulart LR. Risk and protective factors for leprosy development determined by epidemiological surveillance of household contacts. Clin Vaccine Immunol. 2008;15(1):101-5.

Muliyil J, Nelson KE, Diamond EL. Effect of BCG on the risk of leprosy in an endemic area: a case control study. Int J Lepr Other Mycobact Dis. 1991;59(2):229-36.

Araujo S, Rezende MM, Sousa DC, Rosa MR, Santos DC, Goulart LR, et al. Risk-benefit assessment of Bacillus Calmette-Guerin vaccination, anti-phenolic glycolipid I serology, and Mitsuda test response: 10-year follow-up of household contacts of leprosy patients. Rev Soc Bras Med Trop. 2015;48(6):739-45.

Yuan Y, You Y, Wen Y, Liu J, Li H, Zhang Y, et al. Identification of novel genetic loci GAL3ST4 and CHGB involved in susceptibility to leprosy. Sci Rep. 2017;7(1):16352.

Sarkar R, Pradhan S. Leprosy and women. Int J Womens Dermatol. 2016;2(4):117-21.

Additional Files

Published

2020-11-24

How to Cite

Garcia, I. R. ., Santos, A. M. R. T. ., Pereira, P. F. ., & Silva, E. de A. M. da . (2020). Epidemiological analysis of new leprosy cases in an old colony in the State of Minas Gerais (2000-2016). Saúde E Pesquisa, 13(4), 871–877. https://doi.org/10.17765/2176-9206.2020v13n4p871-877

Issue

Vol. 13 No. 4 (2020): out./dez.

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Artigos Originais

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