Development of an anti-acne facial mask based on polyvinyl alcohol

Desenvolvimento de uma máscara facial antiacne a base de álcool polivinílico

Keywords: Acne vulgaris, Cosmetics, Face masks

Abstract

A The objective of the present study was to develop a facial mask using polyvinyl alcohol as a film-forming agent with an anti-acne active ingredient (Punica granatum/pomegranate extract). Formulations with varying concentrations of polyvinyl alcohol were prepared using glycerin and sorbitol as wetting agents. Organoleptic tests, drying tests, film formation assessments, pH measurements, temperature stress, and freeze-thaw cycles were conducted. The formulation containing 10% polyvinyl alcohol and a combination of glycerin and sorbitol demonstrated the best results and was selected for the addition of the active ingredient. The formulations remained stable at room temperature for 60 days, dried efficiently, and formed a removable film. The pH levels of the facial masks were found to be compatible with the skin's pH. Ultimately, an ideal anti-acne facial mask formulation was developed, and it is recommended that efficacy and safety tests be conducted prior to commercialization of the product.

Author Biographies

Nathalia Luiz Dias, Federal Rural University of Rio de Janeiro
Bachelor's degree in pharmacy from the Federal Rural University of Rio de Janeiro. Former scholarship monitor for the Brazilian history discipline at CIEP Brizolão 225 Mário Quintana
Luciana Macedo Brito, Federal Rural University of Rio de Janeiro
Graduated in Pharmacy from the Federal University of Rio de Janeiro (2007), Master's degree in Pharmaceutical Sciences from the Federal University of Rio de Janeiro (2009), PhD in Polymer Science and Technology from the Institute of Macromolecules Professor Eloisa Mano (IMA-UFRJ) ( 2013) with research in the area of ​​polymeric nanocomposites for drug release. She completed a sandwich doctorate at the Technical University of Lisbon working in the area of ​​NMR. She has experience in the field of Pharmacy, working mainly on the following topics: development of polymer nanocomposites, development of pharmaceutical and cosmetic forms containing bioactives. She currently works as an Adjunct Professor at the Faculty of Pharmacy at the Federal Rural University of Rio de Janeiro, responsible for the Pharmacotechnical Cosmetology disciplines.

References

Agência Nacional de Vigilância Sanitária (Brasil). Farmacopeia Brasileira. 6ª ed. Brasília: ANVISA; 2019. Available from: https://www.gov.br/anvisa/pt-br/assuntos/farmacopeia/farmacopeia-brasileira

Araviiskaia E, Layton , A M., Estebaranz, JLL, Ochsendorf F, Micali G. The Synergy between Pharmacological Regimens and Dermocosmetics and Its Impact on Adherence in Acne Treatment. Dermatol Res Pract. 2022. https://doi.org10.1155/2022/3644720

Bagatin E, et al. Acne da mulher adulta: um guia para a prática clínica. An Bras Dermatol. 2019;94(1):62-75. https://doi.org10.1590/abd1806-4841.20198203

Baumann LS. Sistema Baumann de classificação da pele. RBM rev bras med [Internet]. 2008 [cited 2024 Apr 2];29–32. Available from: https://pesquisa.bvsalud.org/portal/resource/pt/lil-497071

Agência Nacional de Vigilância Sanitária (Brasil). Guia de controle de qualidade de produtos cosméticos. 2nd ed. Brasília: ANVISA; 2008. Available from: https://www.gov.br/anvisa/pt-br/assuntos/farmacopeia/farmacopeia-brasileira

Becker LC, et al. Safety Assessment of Glycerin as Used in Cosmetics. Int J Toxicol. 2019;38(Suppl 1):17. https://doi.org10.1177/1091581819883820

Melo J, Gabriel De. Riscos e benfícios da isotretinoína [Internet]. [cited 2024 Apr 2]. Available from: https://fait.revista.inf.br/imagens_arquivos/arquivos_destaque/FwA6AES0O2rXm4J_2021-7-2-16-37-48.pdf

Monteiro GM. Desenvolvimento e caracterização de filmes poliméricos à base de quitosana e carragena para potencial aplicação na cicatrização de feridas [dissertação]. Pelotas: Universidade Federal de Pelotas; 2021. [acesso em 2 de abril de 2024]. Disponível em: https://guaiaca.ufpel.edu.br/bitstream/handle/prefix/8059/Dissertacao_Gabriel_Monteiro_Cholant.pdf?sequence=1&isAllowed=y

Juvonen H, Antikainen O, Lemmens M, Ehlers H, Juppo A. The effect of relative humidity and formulation variables on chewable xylitol-sorbitol tablets. Int J Pharm. 2021;601:120573. https://doi.org/10.1016/j.ijpharm.2021.120573

Costa CO, Maciel LM de S, Pinheiro LBA, Cardoso AM. Qualidade microbiológica de cosméticos industrializados: uma revisão da literatura. RBMC [Internet]. https://doi.org/10.36414/rbmc.v9i23.148

Eghbali S., Askari SF, Avan R, Sahebkar A. Therapeutic Effects of Punica granatum (Pomegranate): An Updated Review of Clinical Trials. J Nutr Metab. 2021 Nov 16;2021:22. https://doi.org/10.1155/2021/5297162

Cho C, Kobayashi T. Advanced cellulose cosmetic facial masks prepared from Myanmar thanaka heartwood. Curr Opin Green Sustain Chem. 2021;27:100413. https://doi.org/10.1016/j.cogsc.2020.100413

Dardir FM, Mohamed AS, Abukhadra MR, Ahmed EA, Soliman MF. Cosmetic and pharmaceutical qualifications of Egyptian bentonite and its suitability as drug carrier for Praziquantel drug. Eur J Pharm Sci. 2018;115:320-329. https://doi.org/10.1016/j.ejps.2018.01.04

Silva FK de S et al. Biocompatible anti-aging face mask prepared with curcumin and natural rubber with antioxidant properties. Int J Biol Macromol. 2023;242(Pt 1):124778. https://doi.org/10.1016/j.ijbiomac.2023.124778

Kuna AC et al. Evaluation of the efficacy and tolerance of a cosmetic serum containing volcanic mineralizing water, probiotic fractions, hyaluronic acid, niacinamide, and tocopherol in patients with "face mask dermatitis". J Am Acad Dermatol. 2022;87(3 Suppl):AB166. https://doi.org/10.1016/j.jaad.2022.06.696.

Heng AHS, Chew FT. Systematic review of the epidemiology of acne vulgaris. Sci Rep. 2020 Apr 1;10(1):5754. https://doi.org/10.1038/s41598-020-62715-3

Lee CJ, Chen, LG, Liang WL, Wang CC. Multiple Activities of Punica granatum Linne against Acne Vulgaris. Int J Mol Sci. 2017 Jan 27;12p. https://doi.org/10.3390/ijms18010141

Lopes AKLC, Carvalho SN, Sousa JPS, Meirelles L. Desenvolvimento e caracterização de máscaras peel-off à base de atapulgita. Research, Society and Development. 2020 Jul 9;v. 9, n. 8, 16 p. https://doi.org/10.33448/rsd-v9i8.5820

Lukić M, Pantelić I, Savić SD. Towards Optimal pH of the Skin and Topical Formulations: From the Current State of the Art to Tailored Products. Cosmetics. 2021 Aug 4;v. 8, n. 69, p. 18. https://doi.org/10.3390/cosmetics8030069

Machado JCB, Ferreira MRA, Soares LAL. Punica granatum leaves as a source of active compounds: A review of biological activities, bioactive compounds, food, and technological application. Food Biosci. 2023;51:102220. https://doi.org/j.fbio.2022.102220

Maphetu N, Unuofin JO, Masuku NP, Olisah C, Lebelo SL. Medicinal uses, pharmacological activities, phytochemistry, and the molecular mechanisms of Punica granatum L. (pomegranate) plant extracts: A review. Biomed Pharmacother. 2022;153:113256. https://doi.org/10.1016/j.biopha.2022.113256

Moga MA, Moga, Dimienescu OG, Bălan A, Dima L, Toma SI, Bîgiu NF, Blidaru A. Pharmacological and Therapeutic Properties of Punica granatum Phytochemicals: Possible Roles in Breast Cancer. Molecules. 2021;26:20p. https://doi.org/10.3390/molecules26041054

Nilforoushzadeh MA et al. Skin care and rejuvenation by cosmeceutical facial mask. JCD Journal of Cosmetic Dermatology. 2018;10p. https://doi.org/10.1111/jocd.12730

Ombredane AS et al. Nanoemulsion-based systems as a promising approach for enhancing the antitumoral activity of pequi oil (Caryocar brasilense Cambess.) in breast cancer cells. J Drug Deliv Sci Technol. 2020;58:101819. https://doi.org/10.1016/j.jddst.2020.101819

Koetting MC, Peters JT, Steichen SD, Peppas NA. Stimulus-responsive hydrogels: Theory, modern advances, and applications. Mater Sci Eng R Rep. 2015;93:1-49. https://doi.org/10.1016/j.mser.2015.04.001

Phimnuan P, Yakaew S, Yosboonruang A, Luangbudnak W, Grandmottet F, Viyoch J. Development of Anti-Acne Film from Bio-Cellulose Incorporating Punica granatum Peel Extract. Walailak J Sci & Tech. 2018 Jun 6;16(10):765-778. https://doi.org/10.48048/wjst.2019.4702

Trevisol TC, Henriques RO, Souza AJA, Cesca K, Furigo A. Starch- and carboxymethyl cellulose-based films as active beauty masks with papain incorporation. Int J Biol Macromol. 2023;231:123258. https://doi.org/10.1016/j.ijbiomac.2023.123258

Saiwaeo S, Arwatchananukul S, Mungmai L, Preedalikit W, Aunsri N. Human skin type classification using image processing and deep learning approaches. Heliyon. 2023;9(11):e21176. https://doi.org/10.1016/j.heliyon.2023.e21176

Silva FVF, et al. Desenvolvimento e controle de qualidade de um gel-creme antiacneico a base do óleo da Copaífera officinalis L. (copaíba). Rev Eletr Acervo Saúde / Electronic J Collection Health, Teresina-PI. 2019 Aug; p. 10. https://doi.org/10.25248/reas.e974.2019

Pozza BMF, Silva KA, Ribeiro BD, Coelho MAZ. Avaliação da estabilidade de emulsões cosméticas elaboradas com saponinas de juá (Ziziphus joazeiro) e sisal (Agave sisalana). Visão Acad. 2017 Feb;17(3). https://doi.org/10.5380/acd.v17i3.49106

Saparbekova AA, Kantureyeva GO, Kudasova DE, Konarbayeva ZK, Latif AS. Potential of phenolic compounds from pomegranate (Punica granatum L.) by-product with significant antioxidant and therapeutic effects: A narrative review. Saudi J Biol Sci. 2023;30(2):103553. https://doi.org/10.1016/j.sjbs.2022.103553 .

Asthana N, Pal K, Aljabali AAA, Tambuwala MM, de Souza FG, Pandey K. Polyvinyl alcohol (PVA) mixed green-clay and aloe vera based polymeric membrane optimization: Peel-off mask formulation for skin care cosmeceuticals in green nanotechnology. J Mol Struct. 2021;1229:129592. https://doi.org/10.1016/j.molstruc.2020.129592

Viana FD, Monteiro CLS, Paes ERC. Formulação de máscara facial de Cúrcuma (Peel-Off) com potencial ação antioxidante. Brazilian Journal of Development, Curitiba. 2022 Jul; v.8, n.7, p. 54587-54605. DOI: https://doi.org/10.34117/bjdv8n7-367

Vieira RP et al. Physical and physicochemical stability evaluation of cosmetic formulations containing soybean extract fermented by Bifidobacterium animalis. Brazilian Journal of Pharmaceutical Science. 2009; 3(45): 517–528. https://doi.org/10.1590/S1984-82502009000300018

Tahir CM. Pathogenesis of acne vulgaris: simplified. J Pak Assoc Dermatol [Internet]. 2016Dec.21 [cited 2024Apr.2];20(2):93-7. Available from: https://www.jpad.com.pk/index.php/jpad/article/view/398

Tescarollo IL. Farmácia e Promoção da Saúde. Atena. 2020; 204 p. https://doi.org/10.22533/at.ed.245200302

Wilkinson JB, Moore RJ. Cosmetologia de Harry. Madrid: Ediciones Diaz de Santos; 1990. p. 1039. ISBN-10: 8487189385, ISBN-13: 978-8487189388.

Powell KC, Damitz R, Chauhan A. Relating emulsion stability to interfacial properties for pharmaceutical emulsions stabilized by Pluronic F68 surfactant. Int J Pharm. 2017;521(1-2):8-18. https://doi.org/10.1016/j.ijpharm.2017.01.058

Rosário MS do, Gauto MIR, Silva ACLN, Sales JS, Pereira F dos S, Santos EP dos. Estudo de estabilidade de emulsão cosmética com potencial de creme hidratante para o tratamento da xerose cutânea utilizando o óleo de babaçu (Orbignya phalerata Martius) / Study of stability of cosmetic emulsion with potential of hydrating cream for the treatment of cutaneous xerosis using babassu oil (Orbignya phalerata Martius). Braz J Develop. 2021;7(3):29552–70. DOI: https://doi.org/10.34117/bjdv7n3-596

Zohra FT, Sultana T, Islam S, Nasreen T. Evaluation of Severity in Patients of Acne Vulgaris by Global Acne Grading System in Bangladesh. Clinical Pathology & Research Journal. 2017 Jun; v. 1, n. 1, p. 5. DOI: https://doi.org/10.23880/cprj-16000105

Khikmatillaevna PS. Improvement of acne therapy taking into account clinical, genetic and biochemical research methods. Art of MedicineVolume-2.International Medical Scientific Journal.Issue-3, 2021. Doi: https://doi.org/10.5281/zenodo.7149265

Souza MC, Sartor CFP, Felipe DF. Comparação da Ação Antioxidante de Uma Formulação Contendo Extrato de Pereskia aculeata com Cosméticos Anti-Idade Presentes no Mercado. Saúde e Pesquisa [Internet]. 2013 Oct 31;6(3). Available from: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/2630

Aquino JS de, Felipe DF. Avaliação da Estabilidade Acelerada de Diferentes Formulações Contendo Vitamina C. Saúde e Pesquisa [Internet]. 2014 [cited 2024 Apr 2];7(1). Available from: https://periodicos.unicesumar.edu.br/index.php/saudpesq/article/view/3021

Published
2024-08-25
Section
Artigos Originais