HEPATIC EVALU ATION IN WISTAR RATS EXPOSED TO AYAHUASCA TEA

Authors

  • Bruno Acharezzi Centro Universitário Barão de Mauá
  • Gabriela Carolina Tangerino Centro Universitário Barão de Mauá
  • Lucas Gabriel Sperandio Centro Universitário Barão de Mauá
  • Ana Claudia Dinamarco Mestriner Centro Universitário Barão de Mauá.
  • Wilson Roberto Malfará Centro Universitário Barão de Mauá.

DOI:

https://doi.org/10.17765/1983-1870.2015v8n3p423-430

Keywords:

Ayahuasca Tea, Liver Morphology, Liver Morphometry, Hepatic Enzymes, Hepatic Biochemistry

Abstract

Ayahuasca tea is employed in Xamanism, in anti-drug therapy and illicitly in hallucinogenic recreations. Current study assesses the liver histologically and biochemically since it is an organ involved in the metabolism of the tea. Twenty-four male adult Wistar rats were divided into two groups (control and treated). A daily dose four times higher than that used within a religious context was given, during four consecutive days. There was no qualitative morphological change but a reduction of hepatocyte volume and its nucleus occurred when the quantitative analysis of the treated group was performed. Biochemical analysis showed a decrease in gamma-glutamyltransferasis and Alkaline Phosphatase. There were no morphological alterations for dose and exposure time in current study. Morphometric analysis showed significant alterations in hepatocyte volume and its nucleus where a decrease in volume of the treated group occurred when compared to that of control. A significant statistical decrease was detected in the gamma-glutamyl-transferasis and alkaline phosphatase parameters. Current analysis also detected a decrease in hepatocyte volume without alterations in hepatic functions and structure.

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Author Biographies

Bruno Acharezzi, Centro Universitário Barão de Mauá

Participante do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Medicina.

Gabriela Carolina Tangerino, Centro Universitário Barão de Mauá

Participante do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Medicina.

Lucas Gabriel Sperandio, Centro Universitário Barão de Mauá

Participante do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Medicina.

Ana Claudia Dinamarco Mestriner, Centro Universitário Barão de Mauá.

Orientadora do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Histologia.

Wilson Roberto Malfará, Centro Universitário Barão de Mauá.

Orientador do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Farmacologia.

Published

2015-12-31

How to Cite

Acharezzi, B., Tangerino, G. C., Sperandio, L. G., Mestriner, A. C. D., & Malfará, W. R. (2015). HEPATIC EVALU ATION IN WISTAR RATS EXPOSED TO AYAHUASCA TEA. Saúde E Pesquisa, 8(3), 423–430. https://doi.org/10.17765/1983-1870.2015v8n3p423-430

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