HEPATIC EVALU ATION IN WISTAR RATS EXPOSED TO AYAHUASCA TEA

  • Bruno Acharezzi Centro Universitário Barão de Mauá
  • Gabriela Carolina Tangerino Centro Universitário Barão de Mauá
  • Lucas Gabriel Sperandio Centro Universitário Barão de Mauá
  • Ana Claudia Dinamarco Mestriner Centro Universitário Barão de Mauá.
  • Wilson Roberto Malfará Centro Universitário Barão de Mauá.
Keywords: Ayahuasca Tea, Liver Morphology, Liver Morphometry, Hepatic Enzymes, Hepatic Biochemistry

Abstract

Ayahuasca tea is employed in Xamanism, in anti-drug therapy and illicitly in hallucinogenic recreations. Current study assesses the liver histologically and biochemically since it is an organ involved in the metabolism of the tea. Twenty-four male adult Wistar rats were divided into two groups (control and treated). A daily dose four times higher than that used within a religious context was given, during four consecutive days. There was no qualitative morphological change but a reduction of hepatocyte volume and its nucleus occurred when the quantitative analysis of the treated group was performed. Biochemical analysis showed a decrease in gamma-glutamyltransferasis and Alkaline Phosphatase. There were no morphological alterations for dose and exposure time in current study. Morphometric analysis showed significant alterations in hepatocyte volume and its nucleus where a decrease in volume of the treated group occurred when compared to that of control. A significant statistical decrease was detected in the gamma-glutamyl-transferasis and alkaline phosphatase parameters. Current analysis also detected a decrease in hepatocyte volume without alterations in hepatic functions and structure.

Author Biographies

Bruno Acharezzi, Centro Universitário Barão de Mauá
Participante do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Medicina.
Gabriela Carolina Tangerino, Centro Universitário Barão de Mauá
Participante do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Medicina.
Lucas Gabriel Sperandio, Centro Universitário Barão de Mauá
Participante do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Medicina.
Ana Claudia Dinamarco Mestriner, Centro Universitário Barão de Mauá.
Orientadora do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Histologia.
Wilson Roberto Malfará, Centro Universitário Barão de Mauá.
Orientador do Programa de Iniciação Científica do Centro Universitário Barão de Mauá. Toxicologia de sistemas orgânicos, naturais e sócio-ambientais. Farmacologia.
Published
2015-12-31
Section
Artigos Originais