Candida species cause vulvovaginitis and resistance to antifungals used for treatment

DOI: https://doi.org/10.17765/2176-9206.2021v14Supl.1.e8022
Keywords: Candida spp., Microbial sensitivity tests, Polymerase chain reaction, Vulvovaginal candidiasis

Abstract

In this study were identified Candida species from vaginal secretion isolates, evaluated their in vitro antifungal susceptibilities, and correlated these features with antifungal agents prescribed for patients assisted in a primary care service. Species identification by Polymerase Chain Reaction showed that 36.5% of isolates were characterized as non-C. albicans species. In antifungal susceptibility tests most isolates were susceptible to ketoconazole, fluconazole, and itraconazole, although between 40% and 50% of isolates show resistance or dose-dependent susceptibility to miconazole and nystatin, respectively. Analysis of drugs prescribed to patients revealed that 34.2% of the isolates were considered resistant to agents used in treatment. Several Candida species can cause vulvovaginitis and exhibit different susceptibility profiles to antifungal drugs used in treatment. The identification of Candida species is relevant and useful to the epidemiological management of infections. The antifungal susceptibility test may also be useful for choosing most effective drug treatment for each patient.

Author Biographies

Diogo Luan de Oliveira, Universidade Comunitária da Região de Chapecó - UNOCHAPECÓ
Pharmacist. Post graduated in Clinical Analysis. Health Sciences. Universidade Comunitária da Região de Chapecó (UNOCHAPECÓ), Chapecó SC Brazil.
Juliana Cristina Schmidt, Universidade Comunitária da Região de Chapecó - UNOCHAPECÓ
Doctor´s degree in Cell and Molecular Biology (UFPR). Professor in Health Sciences and in Postgraduate Courses featuring Laboratory Clinical Diagnosis and Pharmacology at the Universidade Comunitária da Região de Chapecó (UNOCHAPECÓ), Chapecó SC Brazil.

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Published
2021-12-20
Issue
Vol 14 No (Supl. 1) (2021): Supl. 1 - dez.
Section
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