Natural rubber latex and biomembranes in biomedical applications: do its effects justify its use? Látex de borracha natural e biomembranas em aplicações biomédicas: seus efeitos justificam seu uso?

Luciana Mascena Silva; Davide Carlos Joaquim; Arthur Castro de Lima; Ana Karine Rocha de Melo Leite; Ana Caroline Rocha de Melo Leite; Virgínia Cláudia Carneiro Girão-Carmona

doi:10.17765/2176-9206.2025v18e13201

Autores/as

Luciana Mascena Silva Universidade Federal do Ceará https://orcid.org/0000-0002-2101-3017
Davide Carlos Joaquim Universidade Estadual do Ceará https://orcid.org/0000-0003-0245-3110
Arthur Castro de Lima Universidade Federal do Ceará https://orcid.org/0000-0003-1826-2247
Ana Karine Rocha de Melo Leite Universidade Estadual do Ceará https://orcid.org/0000-0003-4135-4545
Ana Caroline Rocha de Melo Leite Universidade da Integração Internacional da Lusofonia Afro-Brasileira https://orcid.org/0000-0002-9007-7970
Virgínia Cláudia Carneiro Girão-Carmona Universidade Federal do Ceará https://orcid.org/0000-0002-0676-8585

DOI:

https://doi.org/10.17765/2176-9206.2025v18e13201

Palabras clave:

Biomaterial, Hevea brasiliensis, Latex, Rubber

Resumen

This study aimed to gather the literature on the biomedical applications of natural rubber latex (NRL). This integrative review, carried out in 2021, based on the guiding question “What are the biomedical applications of NRL?” was developed using the PICO strategy. The combination of the words "Natural Rubber" AND "Biomaterials" was used in the databases' search. The 23 articles addressed, as biomedical objectives/applications, the incorporation of drugs/products into the NRL membrane in phenomena such as microbial action, pain, and adverse events. Regarding the results of this incorporation, the publications indicated an occurrence dependent on the density and size of the pores, in addition to the absence of structural changes and significant interactions with the membrane. Furthermore, the release of the drugs/products was initially rapid. It is concluded that the works focused on research addressing the incorporation of drugs/release products into the NRL membrane, dependent on its inherent properties and with different effects, without harm to other cell types.

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Biografía del autor/a

Luciana Mascena Silva, Universidade Federal do Ceará

Graduada em Biologia pela Universidade Vale do Acaraú (UVA) e doutora em Ciências Morfofuncionais pela Universidade Federal do Ceará (UFC).

Davide Carlos Joaquim, Universidade Estadual do Ceará

Graduado em Enfermagem pela Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB) e doutor em Ciências Morfofuncionais pela Universidade Federal do Ceará (UFC).

Arthur Castro de Lima, Universidade Federal do Ceará

Graduado em Enfermagem pela Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB) e mestrando no Programa de Pós-graduação em Ciências Morfofuncionais da Universidade Federal do Ceará (UFC).

Ana Karine Rocha de Melo Leite, Universidade Estadual do Ceará

Graduada em Ciências Veterinárias pela Universidade Estadual do Ceará (UECE), doutora em Ciências Médicas pela Universidade Federal do Ceará (UFC) e docente da UECE.

Ana Caroline Rocha de Melo Leite, Universidade da Integração Internacional da Lusofonia Afro-Brasileira

Graduada em Odontologia pela Universidade Federal do Ceará (UFC), doutora em Ciências Médicas pela UFC, docente do Curso de Enfermagem, Farmácia e do Programa de Pós-graduação em Enfermagem da UNILAB.

Virgínia Cláudia Carneiro Girão-Carmona, Universidade Federal do Ceará

Graduada em Ciências Veterinárias pela Universidade Estadual do Ceará (UECE), doutora em Farmacologia pela Universidade Federal do Ceará (UFC), docente do Curso de Medicina e do Programa de Pós-graduação em Ciências Morfofuncionais da UFC.

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