Impact of corticosteroid administration on pregnancy outcomes
Impacto do uso de corticosteroides nos desfechos gestacionais
DOI:
https://doi.org/10.17765/2176-9206.2025v18e12500Keywords:
Corticosteroids, Morbidity, Preterm Birth, Respiratory Distress SyndromeAbstract
Objective: To evaluate the impact of corticosteroids on gestational outcomes. Method: Cross-sectional study, with 257 pregnant women, with newborns aged 34 weeks or less, who did or did not receive a corticosteroid cycle. Outcomes assessed: admission to the neonatal ICU (NICU), respiratory distress syndrome (RDS), mechanical ventilation (MV), neurological impairment (NP) and death. Results: They differed in admission to the NICU (70.8% vs 91.4% p=0.000) and need for MV (60.5% vs 81.7% p=0.000). No difference was found in RDS (55.4% vs 64.8% p=0.129), PN (3.1% vs 7.1% p=0.167) and neonatal death (0.8% vs 3.2%p =0.211), with and without corticosteroid use respectively. Conclusion: Corticosteroids had a positive impact on reducing NICU and MV, emphasizing the importance of corticosteroids for a better outcome in premature babies. Keywords: Corticosteroids. Preterm Birth. Respiratory Distress Syndrome. Morbidity.Downloads
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References
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3. Saito K, Nishimura E, Ota E, Namba F, Toshiyuki Swa, Ramson J, et al. Antenatal corticosteroids in specific groups at risk of preterm birth: a systematic review. BMJ Open. 2023 Sep 1;13(9):e065070–0.
4. Roberts D, Brown J, Medley N, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database of Systematic Reviews [Internet]. 2017 Mar 21;3(3). Available from: https://www.cochrane.org/CD004454/PREG_antenatal-corticosteroids-accelerating-fetal-lung-maturation-women-risk-preterm-birth
5. Kimpton J, Sammut A, Cox DJ. Antenatal corticosteroids and longer term outcomes. The BMJ. 2023 Aug 2;p1722–2.
6. Ninan K, Gojic A, Wang Y, Asztalos EV, Beltempo M, Murphy KE, et al. The proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes: systematic review and meta-analysis of 1.6 million infants. BMJ [Internet]. 2023 Aug 2;382:e076035. Available from: https://www.bmj.com/content/382/bmj-2023-076035
7. Puia-Dumitrescu M, Wood TR, Comstock BA, Law JB, German K, Perez KM, et al. Dexamethasone, Prednisolone, and Methylprednisolone Use and 2-Year Neurodevelopmental Outcomes in Extremely Preterm Infants. JAMA Network Open [Internet]. 2022 Mar 11 [cited 2022 Sep 30];5(3):e221947–7. Available from: https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2789922
8. Daskalakis G, Vasilios Pergialiotis, Magnus Domellöf, Ehrhardt H, Di C, Esin Koç, et al. European guidelines on perinatal care: corticosteroids for women at risk of preterm birth. J Matern Fetal Neonatal Med. 2023 Jan 23;36(1).
9. Morhart P, Gartner J, Weiss C, Stumpee FM, Dammer U, Faschingbauer F, et al. Influence of Timing of Antenatal Corticosteroid Administration on Morbidity of Preterm Neonates. In Vivo [Internet]. 2022 Jul 3 [cited 2023 Nov 16];36(4):1777–84. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9301426/
10. Agnew EJ, Ivy JR, Stock SJ, Chapman KE. Glucocorticoids, antenatal corticosteroid therapy and fetal heart maturation. Journal of Molecular Endocrinology [Internet]. 2018 Jul;61(1):R61–73. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5976079/
11. Cole TJ, Short KL, Hooper SB. The science of steroids. Seminars in Fetal & Neonatal Medicine [Internet]. 2019 Jun 1 [cited 2020 Dec 18];24(3):170–5. Available from: https://pubmed.ncbi.nlm.nih.gov/31147162/
12. Thevathasan I, Said J. Controversies in Antenatal Corticosteroid Treatment. Prenatal Diagnosis. 2020 Feb 10;40(9).
13. Dehaene I. Updating the balance between benefits and harms of antenatal corticosteroids requires appropriate causal inference. American Journal of Obstetrics and Gynecology. 2023 Feb;229(1).
14. Almeida FT de, Oliveira RD. Uso de corticosteroides em trabalho de parto prematuro: uma revisão de literatura. dspaceuniceplacedubr [Internet]. 2021 Nov 9; Available from: https://dspace.uniceplac.edu.br/handle/123456789/1406
15. Cartwright RD, Crowther CA, Anderson PJ, Harding JE, Doyle LW, McKinlay CJD. Association of Fetal Growth Restriction With Neurocognitive Function After Repeated Antenatal Betamethasone Treatment vs Placebo: Secondary Analysis of the ACTORDS Randomized Clinical Trial. JAMA network open [Internet]. 2019 Feb 1;2(2):e187636. Available from: https://pubmed.ncbi.nlm.nih.gov/30707225/
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Published
2025-04-13
How to Cite
Godoy, C., Marschall, C., Rossi, R., Selbach, M. D., & Carl Silva, J. (2025). Impact of corticosteroid administration on pregnancy outcomes: Impacto do uso de corticosteroides nos desfechos gestacionais. Saúde E Pesquisa, 18, 12500. https://doi.org/10.17765/2176-9206.2025v18e12500
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