Prevalência da Coinfecção por Trypanosoma cruzi/HIV na mesorregião oeste potiguar, Brasil: Prevalence of Trypanosoma cruzi/ HIV coinfection in the west potiguar messoregion, Brazil

Grináuria  de Sousa Maia Porto; Ellany Gurgel Cosme do Nascimento; Micássio Fernandes de Andrade; Letícia de Lima Mendonça; Thiago Luís de Holanda  Rêgo; Cléber de Mesquita Andrade; Thales Allyrio Araújo de Medeiros Fernandes

doi:10.17765/2176-9206.2025v18e12874

Authors

Grináuria de Sousa Maia Porto State University of Rio Grande do Norte https://orcid.org/0000-0002-6939-3338
Ellany Gurgel Cosme do Nascimento State University of Rio Grande do Norte http://orcid.org/0000-0003-4014-6242
Micássio Fernandes de Andrade State University of Rio Grande do Norte https://orcid.org/0000-0003-2836-9080
Letícia de Lima Mendonça State University of Rio Grande do Norte https://orcid.org/0000-0003-3990-4667
Thiago Luís de Holanda Rêgo State University of Rio Grande do Norte https://orcid.org/0000-0001-7806-8994
Cléber de Mesquita Andrade State University of Rio Grande do Norte https://orcid.org/0000-0002-0264-8842
Thales Allyrio Araújo de Medeiros Fernandes State University of Rio Grande do Norte https://orcid.org/0000-0003-4559-8918

DOI:

https://doi.org/10.17765/2176-9206.2025v18e12874

Keywords:

Acquired Immunodeficiency Syndrome, Chagas Disease, Prevalence, Trypanosoma cruzi HIV coinfection

Abstract

To investigate T. cruzi co-infection in people living with HIV in a reference Unit in the mesoregion of the State of Rio Grande do Norte, Brazil, 993 people living with HIV (PLHIV), performed serology for Chagas disease and levels of TCD4 + and TCD8 + lymphocytes and Viral Load. A 2.6% seroprevalence of T. Cruzi coinfection in PLHIV was found. All are in the chronic phase of CD, with a mean age of 47 years (SD±10.9 and showing social vulnerability. Of these, 46.2% had TCD4 + < 350 cells/mm 3 and 26.9% cell count TCD4 + < 200 cells/mm 3, demonstrating the potential risk of these patients developing CD reactivation. Cardiac involvement was identified in 20.0% of the individuals. Thus, the importance of early identification of co-infection is highlighted, as it enables an adequate therapeutic approach and contributes to the improvement of care, quality of life, and increased survival of people living with HIV.

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Author Biographies

Grináuria de Sousa Maia Porto, State University of Rio Grande do Norte

Master in Health and Society from the State University of Rio Grande do Norte, graduated and licensed in Nursing from the Federal University of Paraíba, Bachelor of Laws from the Faculty of Science and Technology Mater Christi. Specialist in: Auditing of Health Systems, Regulation in Health, Pedagogical Training in Professional Education in the Area of Health-Nursing, Obstetric Nursing, Management of work and education in health, Labor Law and Process and Administrative Law. Internship at the Public Prosecutor's Office of Rio Grande do Norte in the Citizenship/Health Prosecutor's Office. Experience in teaching at the State University of Rio Grande do Norte/PROFAE, SENAC and Postgraduate in the Specialization Course in Health Regulation in the Unified Health System of the Sírio Libanês Institute. She holds the position of Auditor in the Executive Management of Health in Mossoró/RN, nurse of the Government of the State of Rio Grande do Norte at the Rafael Fernandes Hospital, Coordinator of the Human Resources Management Center at the Rafael Fernandes Hospital. She worked in a general hospital and at the Regional Blood Bank of Mossoró. She has experience in the areas of Nursing, Law, Education and Human Resources Management.

Ellany Gurgel Cosme do Nascimento, State University of Rio Grande do Norte

I have a degree in Nursing from the State University of Rio Grande do Norte (UERN) and a PhD in Health Sciences from the Federal University of Rio Grande do Norte (2015). I am a specialist in epidemiology, family health, obstetrics, self-management in health and pedagogical training in nursing. Throughout my professional career, I have worked in primary health care, family health, health management, and teaching in technical and higher education in health. In addition, I played the role of research advisor at the Pro-Rectory of Research and Graduate Studies of UERN, was coordinator of PPGSS/UERN and a permanent professor at PPGCTI/UFERSA. Currently, I hold the position of Adjunct Professor IV in the Undergraduate Course in Medicine at UERN, I am a permanent professor at PPGSS and PROFSAUDE, and I serve as Pro-Rector of Research and Graduate Studies at UERN. My areas of research interest include women's health, human reproduction, gender, chronic and infectious diseases.

Micássio Fernandes de Andrade, State University of Rio Grande do Norte

PhD in Basic and Applied Immunology from the Ribeirão Preto School of Medicine at the University of São Paulo (FMRP-USP), Master in Basic and Applied Immunology from the same institution, graduated in Biological Sciences from the State University of Rio Grande do Norte (UERN). He is currently a Professor of Higher Education, Adjunct A, at the Federal University of Semi-Arid (UFERSA) and Advisor Professor of the Multicenter Postgraduate Program in Biochemistry and Molecular Biology (PMBqBM) and the Postgraduate Program in Health and Society (PPGSS), both linked to the School of Health Sciences at UERN (FACS-UERN). He works mainly with the understanding of the effector functions of human neutrophils and their relationship with the pathogenesis of inflammatory and/or infectious diseases.

Letícia de Lima Mendonça, State University of Rio Grande do Norte

Bachelor of Medicine from the State University of Rio Grande do Norte (2017-2023). Currently, a doctor in the Family Health Strategy through the Mais Médicos Program in the municipality of Baraúna/RN.

Thiago Luís de Holanda Rêgo, State University of Rio Grande do Norte

Bachelor of Medicine from the State University of Rio Grande do Norte - Central Campus (2017-2023). Currently, a physician in the Family Health Strategy in the municipality of Baraúna/RN.

Cléber de Mesquita Andrade , State University of Rio Grande do Norte

Graduated in Medicine from the Federal University of Rio Grande do Norte - UFRN (1998). Residency in Internal Medicine at Hospital Santa Marcelina - São Paulo / SP (2001-2002), with specialist titles in internal medicine and emergency medicine (AMB / SBCM). Residency in Cardiology (2003-2004) and Echocardiography (2005-2006) at the "Dante Pazzanese" Institute of Cardiology - São Paulo / SP, with specialist titles (AMB / SBC). PhD in Health Sciences from UFRN. Currently works as Adjunct Professor of Cardiovascular Diseases and of the Postgraduate Program in Health and Society (PPGSS) at the State University of Rio Grande do Norte - UERN, researcher at the Department of Biosciences of the medical course at UERN.

Thales Allyrio Araújo de Medeiros Fernandes, State University of Rio Grande do Norte

He holds a degree in Pharmacy - Clinical Analysis from the Federal University of Rio Grande do Norte (2002), a Master's degree in Genetics and Molecular Biology from the Federal University of Rio Grande do Norte (2005) and a PhD in Biomedical Sciences from the State University of Campinas (2014). He is currently an Associate Professor at the State University of Rio Grande do Norte, Leader of the Biology and Epidemiology of Infectious and Genetic Diseases Research Group, and Local Coordinator of the Multicenter Postgraduate Program in Biochemistry and Molecular Biology. He has experience in the areas of Human Genetics, Molecular Biology and Medical Education, developing projects in the following themes: Epidemiology and socioeconomic aspects of Genetic Diseases, Influence of genetic characteristics on the clinical evolution of infectious diseases, Biology of Chagas Disease.

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Prevalence of Trypanosoma cruzi/ HIV coinfection in the west potiguar messoregion, Brazil