Combinação de restrição calórica e treinamento resistido em camundongos Swiss machos

Combination of caloric restriction and resistance training in male Swiss mice

Autores

DOI:

https://doi.org/10.17765/2176-9206.2025v18e13000

Palavras-chave:

Adiposidade, Fígado, Glicemia, Metabolismo dos carboidratos

Resumo

Este estudo analisou os efeitos biométricos e bioquímicos da combinação entre restrição calórica (RC) e treinamento resistido intervalado de alta intensidade em escada vertical em camundongos Swiss adultos. A intervenção alimentar (alimento livre, grupo ND; ou RC de 30%, grupo RD) durou 12 semanas. O treinamento dos grupos ocorreu nas semanas 5 a 12. O grupo RD teve ingestão relativa de alimento, massa corporal, perfil lipídico e metabolismo hepático de glicose menores do que o grupo ND. A adiposidade, o metabolismo sistêmico de glicose e o desempenho do grupo RD no treinamento não foram alterados pela RC combinada ao treinamento.

Downloads

Não há dados estatísticos.

Biografia do Autor

Kauane Tomazi Silva, State University of Maringá

Master's Degree in Physiological Sciences at UEM (2022)

Julio Ernesto Perego Junior, State University of Maringá

Master's Degree in Physiological Sciences at UEM (2023)

Ana Luiza Balani Rando, Maringá State University

Master's Degree in Physiological Sciences at UEM (2024)

Rosangela Fernandes Garcia, Maringá State University

Associate Professor of the Department of Physiological Sciences at UEM; permanent member of the Postgraduate Program in Physiological Sciences at UEM

Maria Montserrat Diaz Pedrosa, Universidade Estadual de Maringá

Graduated in Biological Sciences (1991), master's and doctorate in Biological Sciences (Cell Biology) from the State University of Maringá (1999 and 2002). She is currently an associate professor in the Department of Physiological Sciences at the State University of Maringá. She has experience in the area of ​​Physiology, with an emphasis on Physiology of Organs and Systems, working mainly on the following topics: diabetes, dietary restriction, exercise and blood glucose homeostasis. Professor of biophysics, human physiology and animal physiology. Coordinator, advisor and professor of the specialization course in Human Physiology at UEM. Professor and advisor of the Postgraduate Program in Physiological Sciences.

Referências

1. Seo DY, Park SH, Marquez J, Kwak HB, Kim TN, Bae JH, et al. Hepatokines as a molecular transducer of exercise. J Clin Med. 2021;10:385. https://doi.org/10.3390/jcm10030385

2. Hardie DG. Organismal carbohydrate and lipid homeostasis. Cold Spring Harb Perspect Biol. 2012;4:a006031. https://doi.org/10.1101/cshperspect.a006031

3. Smith RL, Soeters MR, Wüst RCI, Houtkooper R H. Metabolic flexibility as an adaptation to energy resources and requirements in health and disease. Endocr Rev. 2018;39:489-517. https://doi.org/10.1210/er.2017-00211

4. François ME, Gillen JB, Little JP. Carbohydrate-restriction with high-intensity interval training: an optimal combination for treating metabolic diseases? Front Nutr. 2017;4:1-10. https://doi.org/10.3389/fnut.2017.00049

5. Mercken EM, Carboneau BA, Krzysik-Walker SM, De Cabo R. Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev. 2012;11(3):390-8. https://doi.org/10.1016/j.arr.2011.11.005

6. Fragala MS, Caixia B, Chaump M, Kaufman HW, Kroll MH. Associations of aerobic and strength exercise with clinical laboratory test values. PLoS One. 2017;12(22):1-22. https://doi.org/10.1371/journal.pone.0180840

7. Anderson RM, Weindruch R. The caloric restriction paradigm: implications for healthy human aging. Am J Human Biol. 2012;24(2):101-6. https://doi.org/10.1002/ajhb.22243

8. Lee SH, Min KJ. Caloric restriction and its mimetics. BMB Rep. 2013;46(4):181-7. https://doi.org/10.5483/BMBRep.2013.46.4.033

9. Branquinho NTD, Cruz GHP, Borrasca CL, Alves LPS, Gomes CRG, Godoi VAF, et al. Early-onset obesity and food restriction alter hepatocyte metabolism in adult Wistar rats. Arch Physiol Biochem. 2017a;123(5):297-305. https://doi.org/10.1080/13813455.2017.1326942

10. Branquinho NTD, Cruz GHP, Silverio AC, Crepaldi LD, Yamada LA, Mariano IR, et al. Rat hepatocyte glucose metabolism is affected by caloric restriction but not by litter size reduction. J Pharm Pharmacol. 2017b;5:408-15. https://doi.org/10.17265/2328-2150/2017.07.003

11. Branquinho NTD, Loiola MS, Crepaldi LD, Yamada LA, Azevedo SC, Bataglini C, et al. Responses of the adult rat glucose metabolism to early life feeding, caloric restriction and refeeding. J Pharm Pharmacol. 2018;6:370-9. https://doi.org/10.17265/2328-2150/2018.04.008

12. Mariano IR, Yamada LA, Soares Rabassi R, Rissi Sabino VL, Bataglini C, Azevedo SCSF, et al. Differential responses of liver and hypothalamus to the nutritional condition during lactation and adult life. Front Physiol. 2020;11:553. https://doi.org/10.3389/fphys.2020.00553

13. Vismara MR, Furlan MM. Parâmetros biométricos como indicadores do grau de desnutrição em ratos sob restrição calórica desde o nascimento. Arq Cienc Saúde Unipar. 2007;11:3-8.

14. Yamada LA, Mariano IR, Sabino VLR, Rabassi RS, Bataglini C, Azevedo SS, et al. Modulation of liver glucose output by free or restricted feeding in the adult rat is independent of litter size. Nutr Metab. 2019;16:86. https://doi.org/10.1186/s12986-019-0413-0

15. Thyfault JP, Bergouignan A. Exercise and metabolic health: beyond skeletal muscle. Diabetologia. 2020;63:1464-74. https://doi.org/10.1007/s00125-020-05177-6

16. Muller GY, Amo AHE, Vedovelli KS, Mariano IR, Bueno GC, Furlan JP, et al. Resistance high-intensity interval training (HIIT) improves acute gluconeogenesis from lactate in mice. Am J Sports Sci. 2019;7:53-9. https://doi.org/10.11648/j.ajss.20190702.12

17. Muller GY, Matos FDO, Perego Jr JE, Kurauti MA, Pedrosa MMD. High-intensity interval resistance training (HIIRT) improves liver gluconeogenesis from lactate in Swiss mice. Appl Physiol Nutr Metab. 2022;47(4):439-46. https://doi.org/10.1139/apnm-2021-0721

18. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.

19. Gaziano JM, Hennekens CH, O'Donnell CJ, Breslow JL, Buring JE. Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation. 1997;96:2520-5. https://doi.org/10.1161/01.cir.96.8.2520

20. Strasser B, Spreitzer A, Haper P. Fat loss depends on energy deficit only, independently of the method for weight loss. Ann Nutr Metab. 2007;51(5):428-32. https://doi.org/10.1159/000111162

21. Bowe JE, Franklin ZJ, Hauge EAC, King AJ, Persaud SJ, Jones PM. Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models. J Endocrinol. 2014;222:G13-25. https://doi.org/10.1530/JOE-14-0182

22. Stumvoll M, Mitrakou A, Pimenta W, Jensen T, Yki-Jarvinen H, Renn W, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000;23(3):295-301. https://doi.org/10.2337/diacare.23.3.295

23. Cederberg H, Laakso M. Obesity and type 2 diabetes. In: Bray GA, Bouchard C, editors. Handbook of obesity: epidemiology, etiology, and physiopathology. Boca Ratón: CRC Press; 2014. p. 539-48.

24. Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2014;444:881-7. https://doi.org/10.1038/nature05488

25. Adeva-Andany MM, Perez FN, Fernandez FC, Donapetry GD, Pazos GC. Liver glucose metabolism in humans. Biosci Rep. 2016;36:1-15. https://doi.org/10.1042/BSR20160385

26. Ashworth W, Perez-Galvan C, Davies N, Bogle IDL. Liver function as an engineering system. AIChE J. 2016;62(9):3285-97. https://doi.org/10.1002/aic.15292

27. Rui L. Energy metabolism in the liver. Compr Physiol. 2014;4(1):177-97. https://doi.org/10.1002/cphy.c130024

28. Trefts E, Williams AS, Wasserman DH. Exercise and the regulation of hepatic metabolism. Progr Molec Biol Transl Sci. 2015;135:203-25. https://doi.org/10.1016/bs.pmbts.2015.07.010

Publicado

23-11-2025

Como Citar

Silva, K. T., Perego Junior, J. E., Rando, A. L. B., Garcia, R. F., & Pedrosa, M. M. D. (2025). Combinação de restrição calórica e treinamento resistido em camundongos Swiss machos : Combination of caloric restriction and resistance training in male Swiss mice . Saúde E Pesquisa, 18, e13000. https://doi.org/10.17765/2176-9206.2025v18e13000

Edição

Seção

Artigos Originais

Artigos mais lidos pelo mesmo(s) autor(es)