Combination of caloric restriction and resistance training in male Swiss mice

Combinação de restrição calórica e treinamento resistido em camundongos Swiss machos

Authors

DOI:

https://doi.org/10.17765/2176-9206.2025v18e13000

Keywords:

Adiposidade, Fígado, Glicemia, Metabolismo de Carboidratos

Abstract

This study analyzed the biometric and biochemical effects of the combination of caloric restriction (CR) and high-intensity interval resistance training on vertical ladder in adult Swiss mice. The feeding regimen (free feeding, group ND; or 30% CR, group RD) lasted 12 weeks. Training took place in weeks from 5 to 12. Group RD had relative food ingestion, body mass, lipid profile and liver glucose metabolism lower than group ND. Adiposity, systemic glucose metabolism and training performance of group RD were not altered by CR combined with training.

Downloads

Download data is not yet available.

Author Biographies

Kauane Tomazi Silva, Universidade Estadual de Maringá

Mestre pelo Programa de Pós-Graduação em Ciências Fisológicas da UEM (2022)

Julio Ernesto Perego Junior, Universidade Estadual de Maringá

Mestre pelo Programa de Pós-Graduação em Ciências Fisiológicas da UEM (2023)

Ana Luiza Balani Rando, Universidade Estadual de Maringá

Mestre pelo Programa de Pós-Graduação em Ciências Fisológicas da UEM (2024)

Rosangela Fernandes Garcia, Universidade Estadual de Maringá

Professora Associada do Departamento de Ciências Fisiológicas da UEM; membro permanente do Programa de Pós-Graduação em Ciências Fisológicas da UEM

Maria Montserrat Diaz Pedrosa, Universidade Estadual de Maringá

Graduação em Ciências Biológicas (1991), mestrado e doutorado em Ciências Biológicas (Biologia Celular) pela Universidade Estadual de Maringá (1999 e 2002) . Atualmente é professora associada do Departamento de Ciências Fisiológicas da Universidade Estadual de Maringá. Tem experiência na área de Fisiologia, com ênfase em Fisiologia de Órgãos e Sistemas, atuando principalmente nos seguintes temas: diabetes, restrição alimentar, exercício e homeostase da glicemia. Docente de biofísica, fisiologia humana e fisiologia animal. Coordenadora, orientadora e professora do curso de especialização em Fisiologia Humana da UEM. Docente e orientadora do Programa de Pós-Graduação em Ciências Fisiológicas.

References

1. Seo DY, Park SH, Marquez J, Kwak HB, Kim TN, Bae JH, et al. Hepatokines as a molecular transducer of exercise. J Clin Med. 2021;10:385. https://doi.org/10.3390/jcm10030385

2. Hardie DG. Organismal carbohydrate and lipid homeostasis. Cold Spring Harb Perspect Biol. 2012;4:a006031. https://doi.org/10.1101/cshperspect.a006031

3. Smith RL, Soeters MR, Wüst RCI, Houtkooper R H. Metabolic flexibility as an adaptation to energy resources and requirements in health and disease. Endocr Rev. 2018;39:489-517. https://doi.org/10.1210/er.2017-00211

4. François ME, Gillen JB, Little JP. Carbohydrate-restriction with high-intensity interval training: an optimal combination for treating metabolic diseases? Front Nutr. 2017;4:1-10. https://doi.org/10.3389/fnut.2017.00049

5. Mercken EM, Carboneau BA, Krzysik-Walker SM, De Cabo R. Of mice and men: the benefits of caloric restriction, exercise, and mimetics. Ageing Res Rev. 2012;11(3):390-8. https://doi.org/10.1016/j.arr.2011.11.005

6. Fragala MS, Caixia B, Chaump M, Kaufman HW, Kroll MH. Associations of aerobic and strength exercise with clinical laboratory test values. PLoS One. 2017;12(22):1-22. https://doi.org/10.1371/journal.pone.0180840

7. Anderson RM, Weindruch R. The caloric restriction paradigm: implications for healthy human aging. Am J Human Biol. 2012;24(2):101-6. https://doi.org/10.1002/ajhb.22243

8. Lee SH, Min KJ. Caloric restriction and its mimetics. BMB Rep. 2013;46(4):181-7. https://doi.org/10.5483/BMBRep.2013.46.4.033

9. Branquinho NTD, Cruz GHP, Borrasca CL, Alves LPS, Gomes CRG, Godoi VAF, et al. Early-onset obesity and food restriction alter hepatocyte metabolism in adult Wistar rats. Arch Physiol Biochem. 2017a;123(5):297-305. https://doi.org/10.1080/13813455.2017.1326942

10. Branquinho NTD, Cruz GHP, Silverio AC, Crepaldi LD, Yamada LA, Mariano IR, et al. Rat hepatocyte glucose metabolism is affected by caloric restriction but not by litter size reduction. J Pharm Pharmacol. 2017b;5:408-15. https://doi.org/10.17265/2328-2150/2017.07.003

11. Branquinho NTD, Loiola MS, Crepaldi LD, Yamada LA, Azevedo SC, Bataglini C, et al. Responses of the adult rat glucose metabolism to early life feeding, caloric restriction and refeeding. J Pharm Pharmacol. 2018;6:370-9. https://doi.org/10.17265/2328-2150/2018.04.008

12. Mariano IR, Yamada LA, Soares Rabassi R, Rissi Sabino VL, Bataglini C, Azevedo SCSF, et al. Differential responses of liver and hypothalamus to the nutritional condition during lactation and adult life. Front Physiol. 2020;11:553. https://doi.org/10.3389/fphys.2020.00553

13. Vismara MR, Furlan MM. Parâmetros biométricos como indicadores do grau de desnutrição em ratos sob restrição calórica desde o nascimento. Arq Cienc Saúde Unipar. 2007;11:3-8.

14. Yamada LA, Mariano IR, Sabino VLR, Rabassi RS, Bataglini C, Azevedo SS, et al. Modulation of liver glucose output by free or restricted feeding in the adult rat is independent of litter size. Nutr Metab. 2019;16:86. https://doi.org/10.1186/s12986-019-0413-0

15. Thyfault JP, Bergouignan A. Exercise and metabolic health: beyond skeletal muscle. Diabetologia. 2020;63:1464-74. https://doi.org/10.1007/s00125-020-05177-6

16. Muller GY, Amo AHE, Vedovelli KS, Mariano IR, Bueno GC, Furlan JP, et al. Resistance high-intensity interval training (HIIT) improves acute gluconeogenesis from lactate in mice. Am J Sports Sci. 2019;7:53-9. https://doi.org/10.11648/j.ajss.20190702.12

17. Muller GY, Matos FDO, Perego Jr JE, Kurauti MA, Pedrosa MMD. High-intensity interval resistance training (HIIRT) improves liver gluconeogenesis from lactate in Swiss mice. Appl Physiol Nutr Metab. 2022;47(4):439-46. https://doi.org/10.1139/apnm-2021-0721

18. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499-502.

19. Gaziano JM, Hennekens CH, O'Donnell CJ, Breslow JL, Buring JE. Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation. 1997;96:2520-5. https://doi.org/10.1161/01.cir.96.8.2520

20. Strasser B, Spreitzer A, Haper P. Fat loss depends on energy deficit only, independently of the method for weight loss. Ann Nutr Metab. 2007;51(5):428-32. https://doi.org/10.1159/000111162

21. Bowe JE, Franklin ZJ, Hauge EAC, King AJ, Persaud SJ, Jones PM. Metabolic phenotyping guidelines: assessing glucose homeostasis in rodent models. J Endocrinol. 2014;222:G13-25. https://doi.org/10.1530/JOE-14-0182

22. Stumvoll M, Mitrakou A, Pimenta W, Jensen T, Yki-Jarvinen H, Renn W, et al. Use of the oral glucose tolerance test to assess insulin release and insulin sensitivity. Diabetes Care. 2000;23(3):295-301. https://doi.org/10.2337/diacare.23.3.295

23. Cederberg H, Laakso M. Obesity and type 2 diabetes. In: Bray GA, Bouchard C, editors. Handbook of obesity: epidemiology, etiology, and physiopathology. Boca Ratón: CRC Press; 2014. p. 539-48.

24. Després JP, Lemieux I. Abdominal obesity and metabolic syndrome. Nature. 2014;444:881-7. https://doi.org/10.1038/nature05488

25. Adeva-Andany MM, Perez FN, Fernandez FC, Donapetry GD, Pazos GC. Liver glucose metabolism in humans. Biosci Rep. 2016;36:1-15. https://doi.org/10.1042/BSR20160385

26. Ashworth W, Perez-Galvan C, Davies N, Bogle IDL. Liver function as an engineering system. AIChE J. 2016;62(9):3285-97. https://doi.org/10.1002/aic.15292

27. Rui L. Energy metabolism in the liver. Compr Physiol. 2014;4(1):177-97. https://doi.org/10.1002/cphy.c130024

28. Trefts E, Williams AS, Wasserman DH. Exercise and the regulation of hepatic metabolism. Progr Molec Biol Transl Sci. 2015;135:203-25. https://doi.org/10.1016/bs.pmbts.2015.07.010

Published

2025-11-23

How to Cite

Silva, K. T., Perego Junior, J. E., Rando, A. L. B., Garcia, R. F., & Pedrosa, M. M. D. (2025). Combination of caloric restriction and resistance training in male Swiss mice : Combinação de restrição calórica e treinamento resistido em camundongos Swiss machos . Saúde E Pesquisa, 18, e13000. https://doi.org/10.17765/2176-9206.2025v18e13000

Issue

Section

Artigos Originais

Most read articles by the same author(s)