Padrão prescritivo de medicamentos para hipertensão arterial sistêmica na atenção primária em saúde: revisão sistemática e meta-análise
DOI:
https://doi.org/10.17765/2176-9206.2021v14n1.e7743Palavras-chave:
Atenção primária em saúde, Diretrizes para prática, Hipertensão arterial sistêmica, Prescrição de medicamentos, Revisão sistemáticaResumo
Investigamos publicações científicas sobre o padrão prescritivo de medicamentos para hipertensão arterial sistêmica e uso de diretrizes na atenção primária em saúde por revisão sistemática e meta-análise. Os artigos foram selecionados nas bases de dados PubMed, Web of Science e LILACS, de acordo com as declarações PRISMA, de 2004 a 2020. A revisão sistemática mostrou um padrão de prescrição superior para terapia combinada (52,9%). A metanálise confirmou a superioridade para a terapia combinada (OR 1,76; IC 1,29 - 2,41). Foi observada maior prevalência de monoterapia no estudo Sueco (98%) e terapia combinada no Nigeriano (98%). Maior frequência prescritiva de inibidores da enzima de conversão da angiotensina em Trinidade (64%); diuréticos (64%), betabloqueadores (63%) e bloqueadores dos canais de cálcio (53%) na Nigéria; e bloqueadores dos receptores da angiotensina (43%) em Portugal. Quanto ao uso das diretrizes, 53% dos estudos relataram a sua utilização na prescrição de anti-hipertensivos na atenção primária em saúde.Downloads
Referências
Roditi G. MR in hypertension. J Magn Reson Imaging. 2011;34(5):989-1006.
James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). Jama. 2014;311(5):507-20
Ram CV, Giles TD. The evolving definition of systemic arterial hypertension. Curr Atheroscler Rep. 2010;12(3):155-8.
Ram CV. Fixed-dose triple-combination treatments in the management of hypertension. Manag Care. 2013;22(12):45-55.
Castano-Guerra R, Medina-Gonzalez Mdel C, de la Rosa-Rincon RL, Loria-Castellanos J. [Clinical guideline for diagnosis and treatment of high blood pressure]. Rev Med Inst Mex Seguro Soc. 2011;49(3):315-24.
Wu KC, Gerstenblith G. Update on newer antihypertensive medicines and interventions. J Cardiovasc Pharmacol Ther. 2010;15(3):257-67.
Heneghan C, Perera R, Mant D, Glasziou P. Hypertension guideline recommendations in general practice: awareness, agreement, adoption, and adherence. Br J Gen Pract. 2007;57(545):948-52.
Petursson H, Getz L, Sigurdsson JA, Hetlevik I. Current European guidelines for management of arterial hypertension: are they adequate for use in primary care? Modelling study based on the Norwegian HUNT 2 population. BMC Fam Pract. 2009;10:70.
Jarari N, Rao N, Peela JR, et al. A review on prescribing patterns of antihypertensive drugs. Clin Hypertens. 2015;22:7.
Ale O, Braimoh RW. Awareness of hypertension guidelines and the diagnosis and evaluation of hypertension by primary care physicians in Nigeria. Cardiovasc J Afr. 2017;28(2):72-6.
Lima SML, Portela MC, Koster I, et al. Utilização de diretrizes clínicas e resultados na atenção básica à hipertensão arterial. Cadernos de Saúde Pública. 2009;25:2001-11.
Cuspidi C, Michev I, Meani S, et al. Awareness of hypertension guidelines in primary care: results of a regionwide survey in Italy. J Hum Hypertens. 2003;17(8):541-7.
Levy J, Gerber LM, Wu X, Mann SJ. Nonadherence to Recommended Guidelines for Blood Pressure Measurement. J Clin Hypertens (Greenwich). 2016;18(11):1157-61.
Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1.
Bastuji-Garin S, Sbidian E, Gaudy-Marqueste C, et al. Impact of STROBE statement publication on quality of observational study reporting: interrupted time series versus before-after analysis. PLoS One. 2013;8(8):e64733.
von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344-9.
Abegaz TM, Shehab A, Gebreyohannes EA, Bhagavathula AS, Elnour AA. Nonadherence to antihypertensive drugs: A systematic review and meta-analysis. Medicine (Baltimore). 2017;96(4):e5641.
DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88.
Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088-1101.
Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Bmj. 1997;315(7109):629-34.
Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Bmj. 2003;327(7414):557-60.
Novello MF, Rosa MLG, Ferreira RT et al. Compliance with the Prescription of Antihypertensive Medications and Blood Pressure Control in Primary Care. Arq Bras Cardiol. 2017;108(2):135-42.
Marquez PHP, Torres OH, San-Jose A, et al. Potentially Inappropriate Antihypertensive Prescriptions to Elderly Patients: Results of a Prospective, Observational Study. Drugs Aging. 2017;34(6):453-66.
Bakare OQ, Akinyinka MR, Goodman O, et al. Antihypertensive use, prescription patterns, and cost of medications in a Teaching Hospital in Lagos, Nigeria. Niger J Clin Pract. 2016;19(5):668-72.
Qvarnstrom M, Kahan T, Kieler H, et al. Persistence to antihypertensive drug classes: A cohort study using the Swedish Primary Care Cardiovascular Database (SPCCD). Medicine (Baltimore). 2016;95(40):e4908.
Cheong AT, Mohd Said S, Muksan N. Time to achieve first blood pressure control after diagnosis among hypertensive patients at primary health care clinics: a preliminary study. Asia Pac J Public Health. 2015;27(2):Np485-94.
Lim KK, Sivasampu S, Khoo EM. Antihypertensive drugs for elderly patients: a cross- sectional study. Singapore Med J. 2015;56(5):291-97.
Clement YN, Ali S, Harripaulsingh S, et al. Drug prescribing for hypertension at primary health care facilities in Trinidad. West Indian Med J. 2012;61(1):43-8.
Chmiel C, Wang M, Senn O, et al. Uncontrolled arterial hypertension in primary care--patient characteristics and associated factors. Swiss Med Wkly. 2012;142:w13693.
Kuehlein T, Laux G, Gutscher A, et al. Diuretics for hypertension--an inconsistency in primary care prescribing behaviour. Curr Med Res Opin. 2011;27(3):497-02.
Buckley B, Shanahan E, Colwell N, Turgonyi E, Bramlage P, Perry IJ. Blood pressure control in hypertensive patients in Irish primary care practices. J Clin Hypertens (Greenwich). 2009;11(8):432-40.
Cortez-Dias N, Martins S, Belo A, Fiuza M. Prevalence and management of hypertension in primary care in Portugal. Insights from the VALSIM study. Rev Port Cardiol. 2009;28(5):499-523.
Jeschke E, Ostermann T, Vollmar HC, et al. Evaluation of prescribing patterns in a German network of CAM physicians for the treatment of patients with hypertension: a prospective observational study. BMC Fam Pract. 2009;10:78.
Akici A, Kalaca S, Ugurlu U, Toklu HZ, Oktay S. Antihypertensive drug utilization at health centres in a district of Istanbul. Pharm World Sci. 2007;29(3):116-21.
Abaci A, Kozan O, Oguz A, et al. Prescribing pattern of antihypertensive drugs in primary care units in Turkey: results from the TURKSAHA study. Eur J Clin Pharmacol. 2007;63(4):397-402.
Chiang CW, Chen CY, Chiu HF, Wu HL, Yang CY. Trends in the use of antihypertensive drugs by outpatients with diabetes in Taiwan, 1997-2003. Pharmacoepidemiol Drug Saf. 2007;16(4):412-21.
Igho-Pemu P, Quarshie A, Oduwole A, et al. Morehouse Community Physicians Network (CPN) hypertension registry: patterns of care and opportunities for targeted medical education. Ethn Dis. 2005;15(4 Suppl 5):S5-120-3.
Al Khaja KA, Sequeira RP, Damanhori AH. Pharmacotherapy and blood pressure control in elderly hypertensives in a primary care setting in Bahrain. Aging Clin Exp Res. 2004;16(4):319-25.
Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation. 2013;127(1):e6-e245.
Varakantham V, Kurakula Sailoo AK, Bharatraj DK. Antihypertensive Prescription Pattern and Compliance to JNC 7 and JNC 8 at Tertiary Care Government Hospital, Hyderabad, India: A Cross-sectional Retrospective Study. Hosp Pharm. 2018;53(2):107-12.
Khubchandani J, Price JH. Association of Job Insecurity with Health Risk Factors and Poorer Health in American Workers. J Community Health. 2017;42(2):242-51.
Liu C, Bayer A, Cosgrove SE, et al. Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus Aureus Infections in Adults and Children. Clinical Infectious Diseases. 2011;52(3):E18-E55.
Delles C, Currie G. Sex differences in hypertension and other cardiovascular diseases. J Hypertens. 2018;36(4):768-70.
Volpe M, Rosei EA, Ambrosioni E, et al. 2012 consensus document of the Italian Society of Hypertension (SIIA): strategies to improve blood pressure control in Italy: from global cardiovascular risk stratification to combination therapy. High Blood Press Cardiovasc Prev. 2013;20(1):45-52.
Sheppard JP, Fletcher K, McManus RJ, Mant J. Missed opportunities in prevention of cardiovascular disease in primary care: a cross-sectional study. Br J Gen Pract. 2014;64(618):e38-46.
Walther D, Curjuric I, Dratva J, et al. High blood pressure: prevalence and adherence to guidelines in a population-based cohort. Swiss Med Wkly. 2016;146:w14323.
Labeit AM, Klotsche J, Pieper L, et al. Changes in the prevalence, treatment and control of hypertension in Germany? A clinical-epidemiological study of 50.000 primary care patients. PLoS One. 2012;7(12):e52229.
Woolsey S, Brown B, Ralls B, Friedrichs M, Stults B. Diagnosing Hypertension in Primary Care Clinics According to Current Guidelines. J Am Board Fam Med. 2017;30(2):170-7.
Jackson JH, Sobolski J, Krienke R, Wong KS, Frech-Tamas F, Nightengale B. Blood pressure control and pharmacotherapy patterns in the United States before and after the release of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guidelines. J Am Board Fam Med. 2008;21(6):512-21.
Wenzel UO, Benndorf R, Lange S. Treatment of arterial hypertension in obese patients. Semin Nephrol. 2013;33(1):66-74.
Pr R, Hv A, Shivamurthy M. Anti hypertensive prescribing patterns and cost analysis for primary hypertension: a retrospective study. J Clin Diagn Res. 2014;8(9):Hc19-22.
Su M, Zhang Q, Bai X, et al. Availability, cost, and prescription patterns of antihypertensive medications in primary health care in China: a nationwide cross-sectional survey. Lancet. 2017;390(10112):2559-68.
Al Badarin FJ, Abuannadi MA, Lavie CJ, O'Keefe JH. Evidence-based diuretic therapy for improving cardiovascular prognosis in systemic hypertension. Am J Cardiol. 2011;107(8):1178-84.
Nishizaka MK, Zaman MA, Calhoun DA. Efficacy of low-dose spironolactone in subjects with resistant hypertension. Am J Hypertens. 2003;16(11 Pt 1):925-30.
Morgado MP, Rolo SA, Pereira L, Castelo-Branco M. Blood pressure control and antihypertensive pharmacotherapy patterns in a hypertensive population of Eastern Central Region of Portugal. BMC Health Serv Res. 2010;10:349.
Garjon J, Saiz LC, Azparren A, et al. First-line combination therapy versus first-line monotherapy for primary hypertension. Cochrane Database Syst Rev. 2017;1:Cd010316.
Hendriksma M, Joosten MH, Peters JP, Grolman W, Stegeman I. Evaluation of the Quality of Reporting of Observational Studies in Otorhinolaryngology - Based on the STROBE Statement. PLoS One. 2017;12(1):e0169316.
Arquivos adicionais
Publicado
Como Citar
Edição
Seção
Licença
A submissão de originais para a revista Saúde e Pesquisa implica na transferência da Carta Concessão de Direitos Autorais, pelos autores, dos direitos de publicação digital para a revista após serem informados do aceite de publicação.A Secretaria Editorial irá fornecer da um modelo de Carta de Concessão de Direitos Autorais, indicando o cumprimento integral de princípios éticos e legislação específica. Os direitos autorais dos artigos publicados nesta revista são de direito do autor, com direitos da revista sobre a primeira publicação. Os autores somente poderão utilizar os mesmos resultados em outras publicações, indicando claramente a revista Saúde e Pesquisa como o meio da publicação original. Em virtude de tratar-se de um periódico de acesso aberto, é permitido o uso gratuito dos artigos, principalmente em aplicações educacionais e científicas, desde que citada a fonte. A Saúde e Pesquisa adota a licença Creative Commons Attribution 4.0 International.
A revista se reserva o direito de efetuar, nos originais, alterações de ordem normativa, ortográfica e gramatical, com vistas a manter o padrão culto da língua e a credibilidade do veículo. Respeitará, no entanto, o estilo de escrever dos autores. Alterações, correções ou sugestões de ordem conceitual serão encaminhadas aos autores, quando necessário. Nesses casos, os artigos, depois de adequados, deverão ser submetidos a nova apreciação. As opiniões emitidas pelos autores dos artigos são de sua exclusiva responsabilidade.
