Pattern prescription drugs for systemic hypertension in primary health care: systematic review and meta-analysis

Authors

DOI:

https://doi.org/10.17765/2176-9206.2021v14n1.e7743

Keywords:

Prescription of drugs, Primary health care, Practice guideline, Systemic hypertension, Systematic review

Abstract

We investigated scientific publications on the prescription pattern of systemic hypertension drugs and use of guidelines in primary health care by systematic review and meta-analysis. Articles were selected in the PubMed, Web of Science and LILACS databases, according to the PRISMA statements, from 2004 to 2020. The systematic review showed a higher prescription pattern for combination therapy (52,9%). The meta-analysis confirmed the superiority of prescription for combination therapy (OR 1.76, CI 1.29 - 2.41). Was observed higher monotherapy prevalence in the Swedish study (98%) and combined therapy in Nigerian (98%). Higher frequency prescriptive of angiotensin-converting enzyme inhibitors in Trinidad (64%); diuretics (64%), beta blockers (63%), and calcium channel blockers (53%) in Nigeria; and angiotensin-receptor blockers (43%) in Portugal. Regarding the use of guidelines, 50% the studies reported their use for the prescription of antihypertensive in primary health care.

Downloads

Download data is not yet available.

Author Biographies

Edilson Almeida de Oliveira, State University of Maringá

Doctoral degree. Postgraduate Program in Biosciences and Pathophysiology (PBF), State University of Maringá (UEM). Pharmacist at Policlínica Dr Primo Marcelo Monteschio, UBS Zona Sul, SMS, PMM, Maringá (PR), Brazil.

Iris Heloísa Pereira Guerra, State University of Maringá

Master degree. Postgraduate Program in Biosciences and Physiopathology (PBF), State University of Maringá (UEM), Maringá PR), Brazil.

Débora Canassa Volpato, State University of Maringá

Master degree. Postgraduate Program in Biosciences and Physiopathology (PBF), State University of Maringá (UEM), Maringá PR), Brazil.

Rogério Toshiro Passos Okawa, State University of Maringá

Permanent professor at the Department of Medicine. State University of Maringá (UEM), Maringá PR), Brazil.

Kesia Palma-Rigo , State University of Maringá

Collaborating professor in Postgraduate Program in Biosciences and Pathophysiology (PBF), State University of Maringá (UEM), Maringá (PR), Brazil.

Thaís da Silva Santos, State University of Maringá

Master degree. Postgraduate Program in Biosciences and Physiopathology (PBF), State University of Maringá (UEM), Maringá PR), Brazil.

Jorge Juarez Vieira Teixeira, State University of Maringá

Permanent professor in Postgraduate Program in Biosciences and Pathophysiology (PBF), State University of Maringá (UEM), Maringá (PR), Brazil.

References

Roditi G. MR in hypertension. J Magn Reson Imaging. 2011;34(5):989-1006.

James PA, Oparil S, Carter BL, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). Jama. 2014;311(5):507-20

Ram CV, Giles TD. The evolving definition of systemic arterial hypertension. Curr Atheroscler Rep. 2010;12(3):155-8.

Ram CV. Fixed-dose triple-combination treatments in the management of hypertension. Manag Care. 2013;22(12):45-55.

Castano-Guerra R, Medina-Gonzalez Mdel C, de la Rosa-Rincon RL, Loria-Castellanos J. [Clinical guideline for diagnosis and treatment of high blood pressure]. Rev Med Inst Mex Seguro Soc. 2011;49(3):315-24.

Wu KC, Gerstenblith G. Update on newer antihypertensive medicines and interventions. J Cardiovasc Pharmacol Ther. 2010;15(3):257-67.

Heneghan C, Perera R, Mant D, Glasziou P. Hypertension guideline recommendations in general practice: awareness, agreement, adoption, and adherence. Br J Gen Pract. 2007;57(545):948-52.

Petursson H, Getz L, Sigurdsson JA, Hetlevik I. Current European guidelines for management of arterial hypertension: are they adequate for use in primary care? Modelling study based on the Norwegian HUNT 2 population. BMC Fam Pract. 2009;10:70.

Jarari N, Rao N, Peela JR, et al. A review on prescribing patterns of antihypertensive drugs. Clin Hypertens. 2015;22:7.

Ale O, Braimoh RW. Awareness of hypertension guidelines and the diagnosis and evaluation of hypertension by primary care physicians in Nigeria. Cardiovasc J Afr. 2017;28(2):72-6.

Lima SML, Portela MC, Koster I, et al. Utilização de diretrizes clínicas e resultados na atenção básica à hipertensão arterial. Cadernos de Saúde Pública. 2009;25:2001-11.

Cuspidi C, Michev I, Meani S, et al. Awareness of hypertension guidelines in primary care: results of a regionwide survey in Italy. J Hum Hypertens. 2003;17(8):541-7.

Levy J, Gerber LM, Wu X, Mann SJ. Nonadherence to Recommended Guidelines for Blood Pressure Measurement. J Clin Hypertens (Greenwich). 2016;18(11):1157-61.

Moher D, Shamseer L, Clarke M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1.

Bastuji-Garin S, Sbidian E, Gaudy-Marqueste C, et al. Impact of STROBE statement publication on quality of observational study reporting: interrupted time series versus before-after analysis. PLoS One. 2013;8(8):e64733.

von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. J Clin Epidemiol. 2008;61(4):344-9.

Abegaz TM, Shehab A, Gebreyohannes EA, Bhagavathula AS, Elnour AA. Nonadherence to antihypertensive drugs: A systematic review and meta-analysis. Medicine (Baltimore). 2017;96(4):e5641.

DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88.

Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088-1101.

Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. Bmj. 1997;315(7109):629-34.

Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. Bmj. 2003;327(7414):557-60.

Novello MF, Rosa MLG, Ferreira RT et al. Compliance with the Prescription of Antihypertensive Medications and Blood Pressure Control in Primary Care. Arq Bras Cardiol. 2017;108(2):135-42.

Marquez PHP, Torres OH, San-Jose A, et al. Potentially Inappropriate Antihypertensive Prescriptions to Elderly Patients: Results of a Prospective, Observational Study. Drugs Aging. 2017;34(6):453-66.

Bakare OQ, Akinyinka MR, Goodman O, et al. Antihypertensive use, prescription patterns, and cost of medications in a Teaching Hospital in Lagos, Nigeria. Niger J Clin Pract. 2016;19(5):668-72.

Qvarnstrom M, Kahan T, Kieler H, et al. Persistence to antihypertensive drug classes: A cohort study using the Swedish Primary Care Cardiovascular Database (SPCCD). Medicine (Baltimore). 2016;95(40):e4908.

Cheong AT, Mohd Said S, Muksan N. Time to achieve first blood pressure control after diagnosis among hypertensive patients at primary health care clinics: a preliminary study. Asia Pac J Public Health. 2015;27(2):Np485-94.

Lim KK, Sivasampu S, Khoo EM. Antihypertensive drugs for elderly patients: a cross- sectional study. Singapore Med J. 2015;56(5):291-97.

Clement YN, Ali S, Harripaulsingh S, et al. Drug prescribing for hypertension at primary health care facilities in Trinidad. West Indian Med J. 2012;61(1):43-8.

Chmiel C, Wang M, Senn O, et al. Uncontrolled arterial hypertension in primary care--patient characteristics and associated factors. Swiss Med Wkly. 2012;142:w13693.

Kuehlein T, Laux G, Gutscher A, et al. Diuretics for hypertension--an inconsistency in primary care prescribing behaviour. Curr Med Res Opin. 2011;27(3):497-02.

Buckley B, Shanahan E, Colwell N, Turgonyi E, Bramlage P, Perry IJ. Blood pressure control in hypertensive patients in Irish primary care practices. J Clin Hypertens (Greenwich). 2009;11(8):432-40.

Cortez-Dias N, Martins S, Belo A, Fiuza M. Prevalence and management of hypertension in primary care in Portugal. Insights from the VALSIM study. Rev Port Cardiol. 2009;28(5):499-523.

Jeschke E, Ostermann T, Vollmar HC, et al. Evaluation of prescribing patterns in a German network of CAM physicians for the treatment of patients with hypertension: a prospective observational study. BMC Fam Pract. 2009;10:78.

Akici A, Kalaca S, Ugurlu U, Toklu HZ, Oktay S. Antihypertensive drug utilization at health centres in a district of Istanbul. Pharm World Sci. 2007;29(3):116-21.

Abaci A, Kozan O, Oguz A, et al. Prescribing pattern of antihypertensive drugs in primary care units in Turkey: results from the TURKSAHA study. Eur J Clin Pharmacol. 2007;63(4):397-402.

Chiang CW, Chen CY, Chiu HF, Wu HL, Yang CY. Trends in the use of antihypertensive drugs by outpatients with diabetes in Taiwan, 1997-2003. Pharmacoepidemiol Drug Saf. 2007;16(4):412-21.

Igho-Pemu P, Quarshie A, Oduwole A, et al. Morehouse Community Physicians Network (CPN) hypertension registry: patterns of care and opportunities for targeted medical education. Ethn Dis. 2005;15(4 Suppl 5):S5-120-3.

Al Khaja KA, Sequeira RP, Damanhori AH. Pharmacotherapy and blood pressure control in elderly hypertensives in a primary care setting in Bahrain. Aging Clin Exp Res. 2004;16(4):319-25.

Go AS, Mozaffarian D, Roger VL, et al. Heart disease and stroke statistics--2013 update: a report from the American Heart Association. Circulation. 2013;127(1):e6-e245.

Varakantham V, Kurakula Sailoo AK, Bharatraj DK. Antihypertensive Prescription Pattern and Compliance to JNC 7 and JNC 8 at Tertiary Care Government Hospital, Hyderabad, India: A Cross-sectional Retrospective Study. Hosp Pharm. 2018;53(2):107-12.

Khubchandani J, Price JH. Association of Job Insecurity with Health Risk Factors and Poorer Health in American Workers. J Community Health. 2017;42(2):242-51.

Liu C, Bayer A, Cosgrove SE, et al. Clinical Practice Guidelines by the Infectious Diseases Society of America for the Treatment of Methicillin-Resistant Staphylococcus Aureus Infections in Adults and Children. Clinical Infectious Diseases. 2011;52(3):E18-E55.

Delles C, Currie G. Sex differences in hypertension and other cardiovascular diseases. J Hypertens. 2018;36(4):768-70.

Volpe M, Rosei EA, Ambrosioni E, et al. 2012 consensus document of the Italian Society of Hypertension (SIIA): strategies to improve blood pressure control in Italy: from global cardiovascular risk stratification to combination therapy. High Blood Press Cardiovasc Prev. 2013;20(1):45-52.

Sheppard JP, Fletcher K, McManus RJ, Mant J. Missed opportunities in prevention of cardiovascular disease in primary care: a cross-sectional study. Br J Gen Pract. 2014;64(618):e38-46.

Walther D, Curjuric I, Dratva J, et al. High blood pressure: prevalence and adherence to guidelines in a population-based cohort. Swiss Med Wkly. 2016;146:w14323.

Labeit AM, Klotsche J, Pieper L, et al. Changes in the prevalence, treatment and control of hypertension in Germany? A clinical-epidemiological study of 50.000 primary care patients. PLoS One. 2012;7(12):e52229.

Woolsey S, Brown B, Ralls B, Friedrichs M, Stults B. Diagnosing Hypertension in Primary Care Clinics According to Current Guidelines. J Am Board Fam Med. 2017;30(2):170-7.

Jackson JH, Sobolski J, Krienke R, Wong KS, Frech-Tamas F, Nightengale B. Blood pressure control and pharmacotherapy patterns in the United States before and after the release of the Joint National Committee on the Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) guidelines. J Am Board Fam Med. 2008;21(6):512-21.

Wenzel UO, Benndorf R, Lange S. Treatment of arterial hypertension in obese patients. Semin Nephrol. 2013;33(1):66-74.

Pr R, Hv A, Shivamurthy M. Anti hypertensive prescribing patterns and cost analysis for primary hypertension: a retrospective study. J Clin Diagn Res. 2014;8(9):Hc19-22.

Su M, Zhang Q, Bai X, et al. Availability, cost, and prescription patterns of antihypertensive medications in primary health care in China: a nationwide cross-sectional survey. Lancet. 2017;390(10112):2559-68.

Al Badarin FJ, Abuannadi MA, Lavie CJ, O'Keefe JH. Evidence-based diuretic therapy for improving cardiovascular prognosis in systemic hypertension. Am J Cardiol. 2011;107(8):1178-84.

Nishizaka MK, Zaman MA, Calhoun DA. Efficacy of low-dose spironolactone in subjects with resistant hypertension. Am J Hypertens. 2003;16(11 Pt 1):925-30.

Morgado MP, Rolo SA, Pereira L, Castelo-Branco M. Blood pressure control and antihypertensive pharmacotherapy patterns in a hypertensive population of Eastern Central Region of Portugal. BMC Health Serv Res. 2010;10:349.

Garjon J, Saiz LC, Azparren A, et al. First-line combination therapy versus first-line monotherapy for primary hypertension. Cochrane Database Syst Rev. 2017;1:Cd010316.

Hendriksma M, Joosten MH, Peters JP, Grolman W, Stegeman I. Evaluation of the Quality of Reporting of Observational Studies in Otorhinolaryngology - Based on the STROBE Statement. PLoS One. 2017;12(1):e0169316.

Published

2021-02-26

How to Cite

Oliveira, E. A. de, Guerra, I. H. P., Volpato, D. C. ., Okawa, R. T. P., Palma-Rigo , K., Santos, T. da S., & Teixeira, J. J. V. (2021). Pattern prescription drugs for systemic hypertension in primary health care: systematic review and meta-analysis. Saúde E Pesquisa, 14(1), 161–173. https://doi.org/10.17765/2176-9206.2021v14n1.e7743

Issue

Section

Artigos de Revisão - Promoção da Saúde