FUNGICIDE POTENTIAL OF ETHANOL EXTRACT OF THE LEAVES OF Solanum acanthodes HOOK ON Candida albicans IN VITRO

  • Mônica Amorim dos Santos Faculdade São Lucas
  • Renato Abreu Lima Universidade Federal do Amazonas - UFAM
Keywords: Solanum acanthodes, Vegetal Extract, Candidiasis.

Abstract

Candida albicans is the main species in fungus infections of the mouth, with a high virulence featured by the adhesion capacity to mouth tissues and biofilm formation. Solanum acanthodes Hook has a wide geographic distribution and may be found in the Amazon forest of Peru, Ecuador and Brazil. Its leaves are used against infections of the urinary pathways, cholesterol, kidney and belly aches and diabetes. Current analysis evaluates the fungicide activity of the ethanol extract of the S. acanthodes leaves on C. albicans in vitro. Discs with a 5 mm-diameter of cultures isolated from the fungus were placed in the center of petri dishes with BDA medium; four filter paper discs, each with 1 mL of a vegetal extract by maceration were symmetrically placed on the periphery of the plates. Positive control consisted of discs without the vegetal extract, whereas negative control discs with a chemical product were used. The assay had a random design with three replications (plates) per treatment. Fungus growth at every 24 hours during six days was evaluated by measuring the colonies. Data underwent analysis of variance and averages were compared by Tukey´s test at 5%. After 144 hours ethanol extract of the S. acanthodes leaves had good results on C. albicans strain. Fungus growth was inhibited (average 2.4) with a higher inhibitory spectrum when compared to that of the chemical product (average 3.4).

Author Biographies

Mônica Amorim dos Santos, Faculdade São Lucas
Acadêmica do curso de Biologia na Faculdade São Lucas
Renato Abreu Lima, Universidade Federal do Amazonas - UFAM
Doutorando em Biodiversidade e Biotecnologia na Universidade Federal do Amazonas – UFAM.
Published
2013-03-12
Section
Artigos Originais